重症肌无力中的神经肌肉接头：乙酰胆碱受体减少。

Neuromuscular junction in myasthenia gravis: decreased acetylcholine receptors.

作者信息

Fambrough D M, Drachman D B, Satyamurti S

出版信息

Science. 1973 Oct 19;182(4109):293-5. doi: 10.1126/science.182.4109.293.

DOI:10.1126/science.182.4109.293

Abstract

The number of acetylcholine receptors was determined in the neuromuscular junctions of eight patients with typical myasthenia gravis and in five controls, by means of (125)1-labeled alpha-bungarotoxin binding. The junctional acetylcholine receptors were reduced in the myasthenic muscles as compared with the controls. This reduction in receptors may account for the defect in neuromuscular transmission in myasthenia gravis.

摘要

通过（125）1标记的α-银环蛇毒素结合法，测定了8例典型重症肌无力患者和5例对照者神经肌肉接头处乙酰胆碱受体的数量。与对照组相比，重症肌无力患者肌肉中的接头处乙酰胆碱受体减少。受体的这种减少可能是重症肌无力神经肌肉传递缺陷的原因。