Gorden P, Lesniak M A, Hendricks C M, Roth J
Science. 1973 Nov 23;182(4114):829-31. doi: 10.1126/science.182.4114.829.
Plasma as well as pituitary immunoreactive human growth hormone (HGH) comprises at least two discrete components which have been designated as "big" HGH and "little" HGH. Using a newly developed radioreceptor assay, which depends on the ability of a substance to compete with labeled HGH for binding sites on cultured human lymphocytes, we find that the big HGH component from both normal and acromegalic subjects has much less activity in the radioreceptor assay than in the radioimmunoassay, whereas the little HGH component has simnilar activity in both assays.
血浆以及垂体免疫反应性人生长激素（HGH）至少包含两种不同的成分，分别被命名为“大”HGH和“小”HGH。使用一种新开发的放射受体测定法，该方法依赖于一种物质与标记的HGH竞争培养的人淋巴细胞上结合位点的能力，我们发现，正常人和肢端肥大症患者的大HGH成分在放射受体测定法中的活性比在放射免疫测定法中低得多，而小HGH成分在两种测定法中的活性相似。
