Ratliff N B, Gerrard J M, White J G
Am J Pathol. 1979 Aug;96(2):567-80.
Desquamation of canine arterial endothelium was induced by stripping the luminal surface of arteries with an inflated embolectomy catheter. The dogs were killed by intravascular perfusion fixation at intervals varying from 2 hours to 12 weeks after the procedure, and the arteries were studied by light microscopy, transmission electron microscopy, and scanning electron microscopy. A heretofore unreported, apparently specific interaction of aggregated platelets and polymorphonuclear leukocytes (PMNs) was observed on the luminal surface of the denuded arteries. This interaction was abolished by the administration of a single dose of aspirin prior to the application of the catheter. These observations suggest that this platelet--PMN interaction is distinctly different from the classic inflammatory reaction, and that it is an integral part of the arterial response to injury that may affect endothelial regeneration.
通过用充气球囊取栓导管剥离动脉腔面来诱导犬动脉内皮剥脱。术后间隔2小时至12周不等的时间，通过血管内灌注固定处死犬，然后用光镜、透射电镜和扫描电镜对动脉进行研究。在剥脱动脉的腔面观察到一种此前未报道的、明显特异性的聚集血小板与多形核白细胞（PMN）的相互作用。在应用导管前给予单剂量阿司匹林可消除这种相互作用。这些观察结果表明，这种血小板 - PMN相互作用明显不同于经典的炎症反应，并且它是动脉损伤反应中可能影响内皮再生的一个组成部分。
