Yamaguchi I, Kopin I J
Am J Physiol. 1979 Sep;237(3):H305-10. doi: 10.1152/ajpheart.1979.237.3.H305.
Sympathetic stimulation in pithed rats elicits increases in blood pressure (BP) and plasma levels of catecholamines. The BP is proportional to the logarithm of the plasma norepinephrine (NE) concentration. Adrenal medullectomy diminishes slightly only the initial phase of the BP responses, whereas bretylium blocks completely the BP response and diminishes by about 70% the increase in plasma NE. Adrenal medullectomy completely prevents the increase in plasma epinephrine (Epi) and diminishes by 30% plasma NE. Plasma levels of NE appear to reflect sympathetic neuronal activity, but the NE at sympathetic nerve endings is responsible for the increase in BP. Epi released from the adrenal medulla may enhance and accelerate the initial BP response, but plays only a minor role after the first 15 s.
在脊髓横断的大鼠中，交感神经刺激会引起血压（BP）升高以及血浆儿茶酚胺水平升高。血压与血浆去甲肾上腺素（NE）浓度的对数成正比。肾上腺髓质切除术仅略微减弱血压反应的初始阶段，而溴苄铵则完全阻断血压反应，并使血浆NE的升高减少约70%。肾上腺髓质切除术完全阻止血浆肾上腺素（Epi）升高，并使血浆NE减少30%。血浆NE水平似乎反映交感神经活动，但交感神经末梢的NE才是血压升高的原因。肾上腺髓质释放的Epi可能会增强并加速初始血压反应，但在最初15秒后仅起次要作用。
