慢性尿毒症状态下的骨矿物质成熟异常。
Abnormal bone mineral maturation in the chronic uremic state.
作者信息
Russell J E, Termine J D, Avioli L V
出版信息
J Clin Invest. 1973 Nov;52(11):2848-52. doi: 10.1172/JCI107480.
Abstract
X-ray diffraction analysis of bone from chronically uremic but nonacidotic rats with normocalcemia and hyperphosphatemia revealed smaller apatite crystals and an increase in the X-ray amorphous mineral fraction when compared to age-matched, pair-fed control animals, indicating less advanced mineral maturation in the uremic animals. Studies in animals with varied degrees of chronic renal insufficiency revealed a progression of the bone crystal maturational defect with advancing uremia.
摘要
对患有慢性尿毒症但无酸中毒、血钙正常且血磷升高的大鼠的骨骼进行X射线衍射分析发现，与年龄匹配、成对喂养的对照动物相比，其磷灰石晶体更小，X射线无定形矿物质部分增加，这表明尿毒症动物的矿物质成熟程度较低。对不同程度慢性肾功能不全动物的研究表明，随着尿毒症病情进展，骨晶体成熟缺陷也在加重。
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