Bayatpour M, Zbitnew A, Dempster G, Miller K R
Can Med Assoc J. 1973 Nov 3;109(9):873 passim.
Coxsackievirus B(4) was isolated from the throat, nose, blood, stools and urine of a 9-year-old boy with acute glomerulonephritis and a pneumonitis. Neutralization test showed a greater than fourfold rise in the antibody titre to coxsackievirus B(4). The antistreptolysin O titre was elevated, but the complement component was within the normal range. The importance of the coxsackievirus B(4) in the pathogenesis of acute glomerulonephritis is clearly indicated; however, further investigations are needed to understand the details of the virus-kidney interaction.
从一名患有急性肾小球肾炎和肺炎的9岁男孩的咽喉、鼻腔、血液、粪便及尿液中分离出柯萨奇病毒B(4)。中和试验显示,针对柯萨奇病毒B(4)的抗体滴度有四倍以上的升高。抗链球菌溶血素O滴度升高,但补体成分在正常范围内。这清楚地表明了柯萨奇病毒B(4)在急性肾小球肾炎发病机制中的重要性;然而,需要进一步研究以了解病毒与肾脏相互作用的细节。