Jacobs J, Kletter D, Superstine E, Hill K R, Lynn B, Webb R A
J Clin Pathol. 1973 Oct;26(10):742-6. doi: 10.1136/jcp.26.10.742.
The chemical stability and anticoagulant activity of heparin (20 U/ml) were studied in five intravenous fluids at room temperature. Heparin remained stable and active for 24 hours in normal saline, but there was a rapid inactivation of 40 to 55% in solutions containing dextrose or lactate, as measured by chemical and biological methods.High concentrations of benzylpenicillin, ampicillin, or methicillin had no effect on heparin activity in normal saline or dextrose 5%: nor was the stability of the penicillins in these fluids affected to any marked extent by the presence of heparin. Ampicillin was, however, found to be unstable in dextrose 5%, and it would be preferable for it not to be added to dextrose infusions. It is concluded that heparin may be given intravenously in normal saline with benzylpenicillin, ampicillin, or methicillin but several other antibiotics were found to be unsuitable for concurrent infusion with heparin.
在室温下，对肝素（20 U/ml）在五种静脉输液中的化学稳定性和抗凝活性进行了研究。肝素在生理盐水中24小时保持稳定且有活性，但通过化学和生物学方法测定，在含有葡萄糖或乳酸盐的溶液中会迅速失活40%至55%。高浓度的苄青霉素、氨苄西林或甲氧西林对生理盐水中或5%葡萄糖溶液中的肝素活性无影响：这些输液中青霉素的稳定性也未因肝素的存在而受到明显影响。然而，发现氨苄西林在5%葡萄糖溶液中不稳定，因此最好不要将其添加到葡萄糖输液中。结论是肝素可与苄青霉素、氨苄西林或甲氧西林在生理盐水中静脉给药，但发现其他几种抗生素不适合与肝素同时输注。
