Manes J L, Taylor H B, Starkloff G B
J Clin Pathol. 1973 Oct;26(10):776-83. doi: 10.1136/jcp.26.10.776.
This study was undertaken to determine the interrelations between clinico-biochemical parameters and hepatic morphology in markedly obese patients. One hundred and sixty-six women and 52 men comprise this series. There was a statistically significant association of carbohydrate metabolism disturbance with increasing age and corpulence and, in women, with hyperuricaemia and morphological alterations of the liver. Menstrual irregularities also correlated well with hepatic morphology. The livers frequently exhibited steatosis, but other morphological changes were mild. Compared with women, men had higher triglyceride values, more severe hepatic involvement, and poorer correlation of carbohydrate disturbances with hepatic histology. The results indicate a central role of the impaired carbohydrate utilization in the biochemical and hepatic alterations of obesity.
本研究旨在确定明显肥胖患者临床生化参数与肝脏形态之间的相互关系。该系列研究包括166名女性和52名男性。碳水化合物代谢紊乱与年龄增长、肥胖相关，在女性中还与高尿酸血症及肝脏形态改变存在统计学上的显著关联。月经不调也与肝脏形态密切相关。肝脏常表现为脂肪变性，但其他形态学改变较轻。与女性相比，男性甘油三酯值更高，肝脏受累更严重，碳水化合物紊乱与肝脏组织学的相关性更差。结果表明，碳水化合物利用受损在肥胖的生化和肝脏改变中起核心作用。
