Perlemuter L, Harif V, Hazard J, Cenac A
Ann Med Interne (Paris). 1979;130(4):219-23.
Diabetic lesions in 25 patients with maturity-onset non-insulin-dependent diabetes, but with neuropathy and even other complications in spite of previous treatment, were studied. Distribution according to the duration of the diabetes and the age of the patients was comparable to that seen in insulin-dependent diabetes. The most frequent lesions are osteoporosis of the metaphysial line, interphalangeal arthrosis, and hallux valgus. A total of 7 perforating plantar ulcers were noted, and the physiopathology was similar to that described in insulin-dependent diabetes. Lowered insulin levels and the neuropathy which this produres are the major etiological factors, but foot deformities such as talipes equinus and/or flat-feet play a determining role. Treatment consists of insulin administration and avoidance of plantar pressure at the site of the lesions.
对25例成年型非胰岛素依赖型糖尿病患者的糖尿病性病变进行了研究，这些患者尽管先前接受过治疗，但仍患有神经病变甚至其他并发症。根据糖尿病病程和患者年龄的分布与胰岛素依赖型糖尿病相似。最常见的病变是干骺端线骨质疏松、指间关节病和拇外翻。共发现7例足底穿通性溃疡，其病理生理与胰岛素依赖型糖尿病中描述的相似。胰岛素水平降低以及由此产生的神经病变是主要病因，但马蹄足和/或扁平足等足部畸形起决定性作用。治疗包括给予胰岛素以及避免病变部位受到足底压力。
