苯乙双胍后肾脏对酸负荷的反应。
Renal response to acid load after phenformin.
作者信息
Rooth G, Bandman U
出版信息
Br Med J. 1973 Nov 3;4(5887):256-7. doi: 10.1136/bmj.4.5887.256.
Abstract
Normally the kidneys respond to an acid load by increased ammonia production. In six patients with adult-type diabetes this response was reduced by a mean 50% after a therapeutic dose of phenformin. The reduced ability to compensate for acid loads may be one factor leading to metabolic acidosis and lactoacidosis sometimes associated with phenformin therapy.
摘要
正常情况下，肾脏通过增加氨的生成来应对酸性负荷。在6例成年型糖尿病患者中，给予治疗剂量的苯乙双胍后，这种反应平均降低了50%。补偿酸性负荷能力的降低可能是导致有时与苯乙双胍治疗相关的代谢性酸中毒和乳酸性酸中毒的一个因素。
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本文引用的文献
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Renal metabolic response to acid base changes. I. Enzymatic control of ammoniagenesis in the rat.肾脏对酸碱变化的代谢反应。I. 大鼠氨生成的酶促调控。
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