Wilimowski M, Witkowska M, Kedzierska L, Barczyńska J, Wojewódzki W, Felsztyńska J
Arch Immunol Ther Exp (Warsz). 1979;27(3):397-405.
The central action and LD50 of 11 new 2,5-substituted derivates of tetrahydropirimidinedione-4,6 with an aryl group at C2 were investigated. The most favorable action was exerted by 2-furfurylamine derivatives with an alkil or benzyl group at C5. These compounds acted in doses of 0.0025--0.01 of their LD50 synergistically with chloral hydrate and strongly with hexobarbital, delayed convulsions induced with pentetrazole and potentiated the central action of DOPA in mice pargyline-inhibited MAO activity. They did not antagonize electrogenic convulsions, amphetamine potentiated motility and the action of reserpine, and had no analgetic action. Their LD50s were 670-- 1660 mg/kg.
对11种新的2,5-二取代四氢嘧啶二酮-4,6衍生物（C2位带有芳基）的中枢作用和半数致死量（LD50）进行了研究。最有利的作用是由C5位带有烷基或苄基的2-糠胺衍生物发挥的。这些化合物以其LD50的0.0025--0.01剂量与水合氯醛协同作用，与己巴比妥强烈协同作用，延迟戊四氮诱导的惊厥，并增强左旋多巴在小鼠中被帕吉林抑制的单胺氧化酶（MAO）活性时的中枢作用。它们不拮抗电源性惊厥，苯丙胺增强运动性和利血平的作用，且无镇痛作用。它们的LD50为670--1660毫克/千克。
