人补体成分C1与免疫复合物结合后依赖C1抑制剂的解离
C1 inhibitor-dependent dissociation of human complement component C1 bound to immune complexes.
作者信息
Sim R B, Arlaud G J, Colomb M G
出版信息
Biochem J. 1979 Jun 1;179(3):449-57. doi: 10.1042/bj1790449a.
Abstract
The interaction of C1 inhibitor with complement component C1 bound to immune complexes was examined by using 125I-labelled C1 subcomponents. The inhibitor binds rapidly to subcomponent C1s, and more slowly to subcomponent C1r. Formation of the C1r-C1 inhibitor complex causes rapid dissociation of subcomponents C1r and C1s from the antibody-antigen-component C1 aggregate. The rate and extent of this release are proportional to C1 Inhibitor concentration and are also dependent on ionic strength. Results obtained with purified C1 Inhibitor, plasma or serum as source of C1 Inhibitor are all closely comparable. Only slight dissociation of subcomponent C1q is observed under the same range of conditions. The implications of the release phenomenon are discussed in relation to the structure of component C1 and the possibility of differential turnover of C1 subcomponents.
摘要
利用¹²⁵I标记的C1亚成分研究了C1抑制剂与结合在免疫复合物上的补体成分C1的相互作用。该抑制剂与C1s亚成分快速结合，与C1r亚成分结合较慢。C1r - C1抑制剂复合物的形成导致C1r和C1s亚成分从抗体 - 抗原 - C1聚集体中快速解离。这种释放的速率和程度与C1抑制剂浓度成正比，并且还取决于离子强度。以纯化的C1抑制剂、血浆或血清作为C1抑制剂来源所获得的结果都非常相似。在相同条件范围内仅观察到C1q亚成分的轻微解离。结合C1成分的结构以及C1亚成分不同周转率的可能性讨论了释放现象的意义。
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