Tatler G L, Baillod R A, Varghese Z, Young W B, Farrow S, Wills M R, Moorhead J F
Br Med J. 1973 Nov 10;4(5888):315-9. doi: 10.1136/bmj.4.5888.315.
An objective radiographic study of erosions, fractures, and periarticular and vascular calcification was made in a series of 135 patients over 10 years of maintenance haemodialysis therapy. The four lesions progressed at different rates, consistent with variation in the response of tissues to a changing biochemical milieu and deficiency in vitamin D metabolites. The half time for development of individual radiographic signs was 3.4 years for vascular calcification, 9 years for fractures, 16 years for periarticular calcification, and 22.9 years for erosions. Calcification of the dorsalis pedis artery seen as a developing ring or tube was an early and valuable sign of disturbed calcium metabolism. In these patients renal osteodystrophy is a chronic condition with a prolonged time course.
对135例接受10年维持性血液透析治疗的患者进行了关于骨侵蚀、骨折以及关节周围和血管钙化的客观影像学研究。这四种病变以不同速率进展，这与组织对不断变化的生化环境的反应差异以及维生素D代谢产物缺乏相一致。各个影像学征象出现的半衰期分别为：血管钙化3.4年，骨折9年，关节周围钙化16年，骨侵蚀22.9年。足背动脉钙化表现为逐渐形成的环状或管状，是钙代谢紊乱的早期且有价值的征象。在这些患者中，肾性骨营养不良是一种病程漫长的慢性病。
