Dormandy J A, Hoare E, Colley J, Arrowsmith D E, Dormandy T L
Br Med J. 1973 Dec 8;4(5892):576-81. doi: 10.1136/bmj.4.5892.576.
Increased blood viscosity has been shown to be an important factor in reducing blood flow in a review and analysis of the history, clinical findings, and haemodynamic, rheological, radiological, and biochemical measurements in 126 patients with intermittent claudication. In some patients increased viscosity seemed to be the determining cause of claudication. A raised plasma fibrinogen was the most common single biochemical abnormality. The results of conventional serum lipid and lipoprotein estimations were abnormal in the series as a whole but did not correlate with clinical findings or flow measurements at individual patient level. There was, however, a significant correlation between some clinical findings and the susceptibility of the red cells to autoxidation.
在一项对126例间歇性跛行患者的病史、临床发现以及血流动力学、流变学、放射学和生化测量结果的回顾与分析中，血液粘度增加已被证明是减少血流的一个重要因素。在一些患者中，粘度增加似乎是跛行的决定性原因。血浆纤维蛋白原升高是最常见的单一生化异常。整个系列中常规血清脂质和脂蛋白估计结果异常，但在个体患者层面上与临床发现或血流测量结果无关。然而，一些临床发现与红细胞自氧化易感性之间存在显著相关性。
