Lukie B E, Sanders M G
Can Med Assoc J. 1973 Dec 15;109(12):1222-7.
A case of intestinal pseudo-obstruction in a 76-year-old man who presented with a six-year history of intermittent vomiting and abdominal pain and a 1(1/2)-year history of diarrhea is described. Investigation demonstrated aperistalsis of the lower esophagus and an unresponsive atonic small intestine. Marked malabsorption was present and appeared due to intestinal bacterial overgrowth consequent to the hypomotility. Autonomic nervous system testing failed to reveal any definite abnormality. Although this disorder is markedly similar to scleroderma involving the gastrointestinal tract, there was only minimal fibrosis of the bowel musculature evident at autopsy and the neural components appeared to be intact. These findings suggest that the basic disorder may be one of smooth muscle dysfunction. Other known causes of pseudo-obstruction could not be demonstrated.
本文描述了一例76岁男性的肠道假性梗阻病例，该患者有6年间歇性呕吐和腹痛病史，以及1年半的腹泻病史。检查显示食管下段无蠕动，小肠无反应且张力缺乏。存在明显的吸收不良，这似乎是由于肠道动力不足导致肠道细菌过度生长所致。自主神经系统测试未发现任何明确异常。尽管这种疾病与累及胃肠道的硬皮病明显相似，但尸检时仅发现肠道肌肉组织有轻微纤维化，神经成分似乎完好无损。这些发现表明，基本疾病可能是平滑肌功能障碍之一。未发现其他已知的假性梗阻病因。
