Mayersohn M, Endrenyi L
Can Med Assoc J. 1973 Nov 17;109(10):989-93.
The relative bioavailability of three commercial ampicillin products was examined in 12 human subjects using a crossover experimental design. Based upon the areas under the ampicillin plasma concentration-time curves after the oral administration of 250 mg. ampicillin and using an analysis of variance technique no statistically significant differences were found between the products examined. These findings are in contrast to those of a recent report and appear to be explained by formulation differences. These relatively minor differences in formulation reflect the importance of formulation variables in providing efficient drug therapy. The intrasubject variation associated with several of these products is quite marked and is consistent with the incomplete and erratic absorption of this antibiotic in man.
采用交叉实验设计，在12名人类受试者中检测了三种市售氨苄西林产品的相对生物利用度。基于口服250毫克氨苄西林后氨苄西林血浆浓度-时间曲线下的面积，并使用方差分析技术，在所检测的产品之间未发现统计学上的显著差异。这些发现与最近一份报告的结果相反，似乎可以用制剂差异来解释。这些制剂中相对较小的差异反映了制剂变量在提供有效药物治疗方面的重要性。与其中几种产品相关的受试者内变异相当明显，并且与这种抗生素在人体内吸收不完全和不稳定一致。
