硝基杂环对DNA合成的抑制作用。I. 与半波还原电位的相关性。
Inhibition of DNA synthesis by nitroheterocycles. I. Correlation with half-wave reduction potential.
作者信息
Olive P L
出版信息
Br J Cancer. 1979 Jul;40(1):89-93. doi: 10.1038/bjc.1979.144.
Abstract
Twenty-one nitroheterocycles, including metronidazole, misonidazole and AF-2, were tested for their ability to inhibit DNA synthesis in mouse L-929 cells growing in culture. All those tested inhibited the rate of incorporation of 3H-thymidine into L cells following drug treatment for 4 h under aerobic conditions. Only 4 drugs reached their limits of solubility before the uptake of 3H-thymidine was inhibited by 50% or more. For the remaining 17, the log of the concentration producing 50% inhibition of incorporation was directly correlated with the half-wave reduction potential of the compound.
摘要
对包括甲硝唑、米索硝唑和AF-2在内的21种硝基杂环化合物进行了测试，以考察它们抑制培养的小鼠L-929细胞中DNA合成的能力。在需氧条件下药物处理4小时后，所有受试化合物均抑制了3H-胸腺嘧啶核苷掺入L细胞的速率。只有4种药物在3H-胸腺嘧啶核苷摄取被抑制50%或更多之前达到了溶解度极限。对于其余17种药物，产生50%掺入抑制作用的浓度对数与该化合物的半波还原电位直接相关。
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