The effects of perhexiline maleate (Pexid) and alcohol on rat liver.
作者信息
McDonald G S
出版信息
Br J Exp Pathol. 1979 Jun;60(3):294-9.
Abstract
Perhexiline maleate is an anti-anginal drug believed to cause liver damage. The possibility that this effect could be potentiated by alcohol has been investigated. Rats fed both the drug and alcohol did not show more severe liver damage than those fed alcohol alone. Livers from rats fed perhexiline alone did not differ from controls. There is no evidence from this study that alcohol potentiates the effect of perhexiline in rat liver. These results may have a bearing in perhexiline-induced liver damage in humans, but clinical studies are required.
摘要
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The effects of perhexiline maleate (Pexid) and alcohol on rat liver.
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The ultrastructure of fatty liver induced by prolonged ethanol ingestion.长期摄入乙醇所致脂肪肝的超微结构
Am J Pathol. 1966 Apr;48(4):535-55.
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Br Med J. 1971 Dec 4;4(5787):586-8. doi: 10.1136/bmj.4.5787.586.
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Liver during perhexiline hypoglycaemia.
Lancet. 1977 Nov 12;2(8046):1028. doi: 10.1016/s0140-6736(77)92922-1.
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Liver damage after perhexiline maleate.
Lancet. 1977 May 14;1(8020):1056. doi: 10.1016/s0140-6736(77)91290-9.
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