Nelsestuen G L
Biochemistry. 1979 Jun 26;18(13):2843-6. doi: 10.1021/bi00580a026.
Mild heating of aqueous mixtures containing 2-deoxyribose, amino compounds, and purines or pyrimidines produces derivatives of the purines and pyrimidines in high yield. Among the major products formed are 2,3-dideoxy-3-(1'-pyrimidino)pentose and 2,3-dideoxy-3-(9'-purino)pentose. The mechanism of the reaction includes amine-catalzyed dehydration of the alpha, beta positions of the sugar followed by addition of the purine or pyrimidine to the double bond. Rapid addition of purines and pyrimidines to alpha, beta-unsaturated carbonyl compounds (such as acrolin) is a general phenomenon which does not require an amine catalyst. While multiple derivatization of the purines will take place, the N-9 derivative is formed first.
对含有2-脱氧核糖、氨基化合物以及嘌呤或嘧啶的水性混合物进行温和加热，能高产率地生成嘌呤和嘧啶的衍生物。形成的主要产物包括2,3-二脱氧-3-(1'-嘧啶基)戊糖和2,3-二脱氧-3-(9'-嘌呤基)戊糖。该反应的机制包括胺催化糖的α、β位脱水，随后嘌呤或嘧啶加成到双键上。嘌呤和嘧啶快速加成到α,β-不饱和羰基化合物（如丙烯醛）是一种普遍现象，不需要胺催化剂。虽然嘌呤会发生多重衍生化，但首先形成的是N-9衍生物。
