[Ionic balance during cultivation of cell populations in a spatially homogeneous medium].

In culture medium many ionic reactions proceed. Extracellular substances and the cell proper participate in these reactions. For the analysis of ionic processes proceeding in this system the classical approach of physical chemistry is broadened, the effect of flow and cells being taken into account. Fast and slow variables are divided. Ionic equilibria in culture medium are subjected to the same laws as in the absence of the flow and cells. Slow variables are common concentrations of substances of each type. An equation for the cell charge is derived. The set of equations derived describes the dependence of pH culture medium, concentration of the biomass, substrates, metabolic products, charge of these substances on flow rates and metabolism stechiometry.