Samsa J M, Baker P C, Hoff K M
Biol Neonate. 1979;35(5-6):249-54. doi: 10.1159/000241181.
Mice between the ages of 1 day postpartum and adulthood were exposed to the monoamine oxidase inhibitors tranylcypromine and pargyline. The mice were killed at seven different times following drug injection and assayed in vitro for monoamine oxidase activity in four brain regions. Inhibition and recovery of monoamine oxidase activity varied by age, and with the two inhibitors used. During the early maturational period, the potential for new monoamine oxidase synthesis was greater than normal maturational patterns of increase would suggest; and during later maturation either the proportions of various monoamine oxidase forms or their rates of synthesis are different.
将产后1天至成年期的小鼠暴露于单胺氧化酶抑制剂反苯环丙胺和优降宁中。在注射药物后的七个不同时间点处死小鼠，并在体外测定四个脑区的单胺氧化酶活性。单胺氧化酶活性的抑制和恢复因年龄以及所使用的两种抑制剂而异。在早期成熟阶段，新的单胺氧化酶合成潜力大于正常成熟模式下增加的潜力；而在后期成熟过程中，各种单胺氧化酶形式的比例或其合成速率有所不同。
