Zanartu J, Dabancens A, Rodriguez-Bravo R, Barsby F, Schally A V
Obstet Gynecol. 1975 Apr;45(4):443-50.
Human ovarian responses to FSH- and LH-releasing hormone (FSH/LH-RH) were observed at laparotomy and studies by histologic and histochemical examination of ovarian biopsy specimens. The responses were compared to those induced by human menopausal gonadotropin (HMG) and human chorionic gonadotropin (HCG) singly and together. The subjects were healthy, fertile, young women rendered anovulatory by injections of depomedroxyprogesterone acetate (DMPA) or depochlormadinone acetate (CA). Supplementary studies included measurement of urinary pregnanediol, examination of the cervix and vagina for estrogenic and progestational responses, and endometrial biopsy, Both HMG and HCG induced follicular growth and proliferation of granulosa and theca cells, but neither, when given alone, induced ovulation or corpus luteum formation. When given in conjunction they induced single or multiple ovulations and corpora lutea in 11 of 18 women treated. FSH/LH-RH CONSISTENTLY STIMULATED FOLLICULAR DEVELOPMENT AND INDUCED OVULATION IN 2 OF 16 WOMEN TREATED. Preovulatory mature follicles were found in 3 more. FSH/LH-RH may prove to be useful in the treatment of some cases of anovulatory sterility of hypothalamic origin.
在剖腹手术中观察了人类卵巢对促卵泡激素和促黄体生成激素释放激素（FSH/LH-RH）的反应，并通过对卵巢活检标本进行组织学和组织化学检查进行了研究。将这些反应与单独及联合使用人绝经期促性腺激素（HMG）和人绒毛膜促性腺激素（HCG）所诱导的反应进行了比较。研究对象为健康、可育的年轻女性，她们因注射醋酸甲羟孕酮（DMPA）或醋酸氯地孕酮（CA）而导致无排卵。补充研究包括测定尿孕二醇、检查宫颈和阴道的雌激素和孕激素反应以及进行子宫内膜活检。HMG和HCG均能诱导卵泡生长以及颗粒细胞和卵泡膜细胞的增殖，但单独使用时均不能诱导排卵或黄体形成。联合使用时，在18名接受治疗的女性中有11名诱导了单次或多次排卵及黄体形成。FSH/LH-RH在16名接受治疗的女性中有2名持续刺激卵泡发育并诱导排卵。另外在3名女性中发现了排卵前成熟卵泡。FSH/LH-RH可能被证明对治疗某些下丘脑源性无排卵性不育病例有用。
