胆红素对Gunn大鼠中双香豆素的分布、消除及抗凝作用的影响 -1-2 (38547)

Effect of bilirubin on the distribution, elimination and anticoagulant action of dicumarol in Gunn rats-1-2 (38547).

作者信息

Wingard L B, Oie S, Levy G

出版信息

Proc Soc Exp Biol Med. 1975 Feb;148(2):397-401. doi: 10.3181/00379727-148-38547.

Abstract

Jaundiced Gunn rats were found to have a significantly larger apparent volume of distribution and higher rate constant for elimination of dicumarol than their nonjaundiced littermates. Anticoagulant effect-log plasma dicumarol concentration lines were parallel in the two groups of animals, with the line for the jaundiced rats shifted to a lower concentration range. In vitro studies showed that bilirubin can displace dicumarol from serum protein binding sites. There are indications of a genetic influence on the distribution and anticoagulant effect of dicumarol in Gunn rats.

摘要

研究发现，黄疸型冈恩大鼠与非黄疸型同窝仔鼠相比，双香豆素的表观分布容积显著更大，消除速率常数更高。两组动物的抗凝效应-对数血浆双香豆素浓度曲线平行，黄疸型大鼠的曲线移至较低浓度范围。体外研究表明，胆红素可从血清蛋白结合位点置换双香豆素。有迹象表明，基因对冈恩大鼠体内双香豆素的分布及抗凝效应有影响。