心脏浦肯野纤维中的正向动态电流及其失活特性。
The positive dynamic current and its inactivation properties in cardiac Purkinje fibres.
作者信息
Fozzard H A, Hiraoka M
出版信息
J Physiol. 1973 Nov;234(3):569-86. doi: 10.1113/jphysiol.1973.sp010361.
Abstract
- The positive dynamic current in sheep cardiac Purkinje fibres was studied using ;voltage clamp' technique. The major portion of this current was carried by Cl(-) ions.2. A pre-step in membrane potential changed the response of this current to a subsequent depolarization in a way that is similar to the Na inactivation process described by Hodgkin & Huxley (1952a, b).3. Recovery of this current after its activation could be described reasonably well by a single exponential process, and the time course of the recovery varied with membrane voltage.4. The relation of steady-state inactivation of the current to membrane voltage showed a sigmoid shape, varying from 100% at membrane potential of -30 mV to 0% at -80 mV. The membrane potential at 50% inactivation was -53 mV.5. The Cl(-) current may play a role in the shape of the Purkinje fibre action potential, but exact definition depends on determining the voltage and time dependence of all the ionic currents that flow during the plateau.
摘要
使用“电压钳”技术研究了绵羊心脏浦肯野纤维中的正向动态电流。该电流的主要部分由Cl(-)离子携带。
膜电位的预阶跃改变了该电流对随后去极化的响应，其方式类似于霍奇金和赫胥黎（1952a，b）描述的Na失活过程。
该电流激活后的恢复可以通过单个指数过程较好地描述，并且恢复的时间进程随膜电压而变化。
电流稳态失活与膜电压的关系呈S形，在膜电位为-30 mV时为100%，在-80 mV时为0%。50%失活时的膜电位为-53 mV。
Cl(-)电流可能在浦肯野纤维动作电位的形态中起作用，但确切定义取决于确定平台期流动的所有离子电流的电压和时间依赖性。
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