5-氟尿嘧啶和阿霉素对先天性无胸腺（裸）小鼠体内诺布尔大鼠前列腺肿瘤异种移植的影响。

The effect of 5-fluorouracil and adriamycin on heterotransplantation of Noble rat prostatic tumors in congenitally athymic (nude) mice.

作者信息

Drago J R, Maurer R E, Gershwin M E, Eckels D, Palmer J M

出版信息

Cancer. 1979 Aug;44(2):424-30. doi: 10.1002/1097-0142(197908)44:2<424::aid-cncr2820440208>3.0.co;2-#.

DOI:10.1002/1097-0142(197908)44:2<424::aid-cncr2820440208>3.0.co;2-#

Abstract

The Nb rat prostatic adenocarcinoma is a well-characterized, hormonally induced family of tumors that are all readily transplantable into congenitally athymic (nude) mice. Because of this versatile heterotransplantation model, multiple replicate copies of individual tumors can be studied "in rodent." We have extended this by studying the chemotherapeutic response of such tumors and believe that this provides a useful avenue for evaluation of cytotoxic agents. Indeed, this combination of both animal model systems may provide a useful experimental tool to evaluate tumor growth, histopathologic changes and responsiveness to appropriate therapy. We report herein that two Nb rat prostatic carcinomas (2 Pr-129-D-11A and Pr-90) and thie responsiveness to Adriamycin and 5-fluorouracil are objective by studying both growth rates and tumor histology.

摘要

Nb大鼠前列腺腺癌是一种特征明确的、激素诱导的肿瘤家族，所有这些肿瘤都很容易移植到先天性无胸腺（裸）小鼠体内。由于这种通用的异种移植模型，可以在“啮齿动物”中研究单个肿瘤的多个复制副本。我们通过研究此类肿瘤的化疗反应扩展了这一研究，并认为这为评估细胞毒性药物提供了一条有用的途径。事实上，这两种动物模型系统的结合可能为评估肿瘤生长、组织病理学变化以及对适当治疗的反应提供一个有用的实验工具。我们在此报告，通过研究生长速率和肿瘤组织学，两种Nb大鼠前列腺癌（2 Pr-129-D-11A和Pr-90）对阿霉素和5-氟尿嘧啶的反应是客观的。