Craig-Holmes A P, Moore F B, Shaw M W
Am J Hum Genet. 1975 Mar;27(2):178-89.
An analysis of the inherited pattern of C-band heterochromatin has been made in five pedigrees containing a total of 33 offspring that were available for analysis. The majority of variants were found to be inherited; however, at least seven of the 99 variants were not present in either parent, and an additional seven differed from the parental variant by either a morphological change or the appearance of mosaicism. It is believed that the polymorphism of human constitutive heterochromatin arises from a mismatching of the repetitive DNA sequences contained in these regions with subsequent unequal crossing over. Further, the observed mosaic patterns provide suggestive evidence that such an event occurs in somatic cells as well as during meiosis.
对五个家系中的C带异染色质遗传模式进行了分析，这些家系共有33个后代可供分析。发现大多数变异是可遗传的；然而，99个变异中至少有7个在父母双方中都不存在，另外7个与亲本变异在形态变化或嵌合现象上有所不同。据信，人类组成型异染色质的多态性源于这些区域所含重复DNA序列的错配以及随后的不等交换。此外，观察到的嵌合模式提供了暗示性证据，表明这种事件在体细胞以及减数分裂过程中都会发生。
