Doneda L, Conti A F, Gualandri V, Larizza L
Cancer Genet Cytogenet. 1987 Aug;27(2):261-8. doi: 10.1016/0165-4608(87)90008-2.
Chromosome 1 C-band length mosaicism was detected in lymphocytes from six tumor patients and one healthy subject belonging to three families with a high incidence of cancer. In all cases the variant cell population showed a decreased amount of C-heterochromatin in one chromosome, whereas the C-banded pattern of the homolog was identical to that of the nonvariant cell population. A family tendency to unequal mitotic crossing over, possibly leading to C-band heteromorphism, may explain the high frequency of detection of C-heterochromatin mosaicism in cancer family members (seven of 13 cases studied). The possible role of heterochromatin in inducing cancer has been widely discussed. The special feature of the acquired C-band variants vis-à-vis the inherited ones is that they mark intrinsic genetic instability that may result, through multiple mechanisms, in increased susceptibility to malignancy.
在来自三个癌症高发家族的六名肿瘤患者和一名健康受试者的淋巴细胞中检测到1号染色体C带长度嵌合体。在所有病例中，变异细胞群体在一条染色体上显示出C异染色质数量减少，而同源染色体的C带模式与非变异细胞群体的相同。家族性不等有丝分裂交换倾向（可能导致C带异质性）可能解释了癌症家族成员中C异染色质嵌合体的高检出频率（13例研究中有7例）。异染色质在诱发癌症中的可能作用已被广泛讨论。获得性C带变异相对于遗传性变异的特殊之处在于，它们标志着内在的遗传不稳定性，这种不稳定性可能通过多种机制导致对恶性肿瘤易感性增加。
