Grosvenor C E, Mena F, Whitworth N S
Endocrinology. 1979 Oct;105(4):884-7. doi: 10.1210/endo-105-4-884.
The effect of ether inhalation upon plasma PRL levels was assessed in lactating rats whose pituitary stores of the hormone first had been depleted by a short term (10-min) period of suckling in comparison with those whose PRL stores had not been depleted by prior suckling. Ether, unlike suckling or handling-decapitation stress, did not deplete pituitary PRL and caused only a small increase (36 to 52 ng/ml) in the plasma concentration of the hormone. However, when ether was given 10, 60, or 120 min after the plasma concentration had subsided from a prior 10-min period of suckling, the plasma concentration of PRL in each instance rose within 5--10 min to 200--250 ng/ml and was sustained at that level for the remainder of the 30-min exposure period. The amplitude and profile of the plasma PRL concentration after ether inhalation were similar to those obtained when a second suckling, rather than ether, was administered after the short term suckling. These data support the hypothesis that releasable PRL derives from depleted PRL and also indicate that, once it is formed, releasable PRL remains available for discharge into the circulation for a relatively long period of time.
在泌乳大鼠中评估了吸入乙醚对血浆催乳素（PRL）水平的影响，将垂体中该激素储备首先因短期（10分钟）哺乳而耗尽的大鼠与催乳素储备未因先前哺乳而耗尽的大鼠进行比较。与哺乳或断头处理应激不同，乙醚不会耗尽垂体PRL，只会使该激素的血浆浓度略有升高（36至52纳克/毫升）。然而，当在血浆浓度从先前10分钟的哺乳期消退后10、60或120分钟给予乙醚时，每次PRL的血浆浓度在5-10分钟内升至200-250纳克/毫升，并在30分钟的暴露期剩余时间内维持在该水平。吸入乙醚后血浆PRL浓度的幅度和曲线与在短期哺乳后进行第二次哺乳而非吸入乙醚时所获得的相似。这些数据支持了可释放的PRL源自耗尽的PRL这一假说，并且还表明，一旦形成，可释放的PRL在相当长的一段时间内仍可用于释放到循环中。
