大脑中的性激素代谢：中枢作用药物对大鼠间脑中5α-还原作用的影响。
Sex hormones metabolism in the brain: influence of central acting drugs on 5 alpha-reduction in rat diencephalon.
作者信息
Kaneyuki T, Kohsaka M, Shohmori T
出版信息
Endocrinol Jpn. 1979 Jun;26(3):345-51. doi: 10.1507/endocrj1954.26.345.
Rats after adrenalectomy-testectomy showed a gradual increase in diencephalon 3-oxo-5 alpha-steroid: (acceptor) delta4-oxidoreductase (5 alpha-reductase) activity for 3 days. The activity then returned near to the normal range on the 4th postoperative day. When rats were given testosterone propionate (TP) 3 days after adrenalectomy-testectomy, diencephalon 5 alpha-reductase activity returned to the preoperative range 2 hr after TP administration. Diencephalon 5 alpha-reductase activity showed a highly significant increase (p less than 0.01) after a single administration of carbamazepine, reserpine, diazepam, phenytoin, phenobarbital or disulfiram. A significant increase (p less than 0.05) was also found after a single administration of methylphenidate, caffeine or methamphetamine. Plasma testosterone decreased concurrently after administration of all these agents, except diazepam. Diencephalon enzyme activity decreased significantly after repeated disulfiram administrations (p less than 0.01) but increased significantly after methamphetamine administrations (p less than 0.05). Plasma testosterone showed a tendency to decrease after repeated methamphetamine administrations but tended to increase after repeated disulfiram administrations.
肾上腺切除-睾丸切除术后的大鼠，其间脑3-氧代-5α-类固醇：（受体）δ4-氧化还原酶（5α-还原酶）活性在3天内逐渐升高。然后在术后第4天，该活性恢复至接近正常范围。在肾上腺切除-睾丸切除术后3天给大鼠注射丙酸睾酮（TP），给药后2小时，间脑5α-还原酶活性恢复到术前范围。单次给予卡马西平、利血平、地西泮、苯妥英、苯巴比妥或双硫仑后，间脑5α-还原酶活性显著升高（p<0.01）。单次给予哌甲酯、咖啡因或甲基苯丙胺后也发现有显著升高（p<0.05）。除地西泮外，给予所有这些药物后血浆睾酮同时降低。重复给予双硫仑后间脑酶活性显著降低（p<0.01），但重复给予甲基苯丙胺后显著升高（p<0.05）。重复给予甲基苯丙胺后血浆睾酮呈降低趋势，而重复给予双硫仑后呈升高趋势。
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