Kruse K, Bartels H
Eur J Pediatr. 1979 Aug;131(4):247-54. doi: 10.1007/BF00444345.
A 9 year old girl with idiopathic Fanconi syndrome and hypercalciuria is described. In order to determine whether the increased calcium excretion was directly or indirectly due to the disturbed phosphate metabolism, the behavior of the calcium excretion during therapy, the serum levels of 1,25-dihydroxyvitamin D and parathyroid hormone, and the effect of parathyroid hormone on the renal tubules were investigated. Normal serum 1,25-dihydroxyvitamin D and parathyroid hormone levels, lack of a correlation between the serum phosphate concentration and the degree of hypercalciuria, as well as unsuccessful therapy of the hypercalciuria with oral phosphate indicate that the increased calcium excretion cannot be explained by impaired renal phosphate reabsorption. The hypercalciuria in the patient was therefore regarded as being due to a primary decrease of tubular calcium reabsorption.
本文描述了一名患有特发性范科尼综合征和高钙尿症的9岁女孩。为了确定钙排泄增加是直接还是间接由于磷酸盐代谢紊乱所致，研究了治疗期间钙排泄的情况、血清1,25 - 二羟维生素D和甲状旁腺激素水平，以及甲状旁腺激素对肾小管的影响。血清1,25 - 二羟维生素D和甲状旁腺激素水平正常，血清磷酸盐浓度与高钙尿症程度之间缺乏相关性，以及口服磷酸盐治疗高钙尿症未成功，表明钙排泄增加不能用肾磷酸盐重吸收受损来解释。因此，该患者的高钙尿症被认为是由于肾小管钙重吸收原发性减少所致。
