Kitabgi P, Freychet P
Eur J Pharmacol. 1979 Jul 1;56(4):403-6. doi: 10.1016/0014-2999(79)90272-3.
Neurotensin contracted the isolated longitudinal smooth muscle strip of the guinea-pig ileum, but was only 22% as effective as histamine. Neostigmine (0.1 micrometer) increased the effectiveness of neurotensin 4-fold. Atropine (0.1 micrometer) completely inhibited the contracting effect of neurotensin measured in the presence of neostigmine, whereas hexamethonium (0.1 micrometer) was without effect. It is concluded that in the longitudinal smooth muscle of the guinea-pig ileum, the contracting effect of neurotensin is mediated by the release of acetylcholine from nerve endings in response to a postganglionic stimulation of cholinergic nerve fibers.
神经降压素使豚鼠回肠的离体纵行平滑肌条收缩，但效力仅为组胺的22%。新斯的明（0.1微摩尔）使神经降压素的效力提高了4倍。阿托品（0.1微摩尔）完全抑制了在新斯的明存在时所测得的神经降压素的收缩作用，而六甲铵（0.1微摩尔）则无此作用。得出的结论是，在豚鼠回肠的纵行平滑肌中，神经降压素的收缩作用是通过胆碱能神经纤维节后刺激引起神经末梢释放乙酰胆碱来介导的。
