分离的肝细胞对牛磺胆酸盐和吲哚菁绿摄取的不同钠离子需求。
Disparate Na+-requirement of taurocholate and indocyanine green uptake by isolated hepatocytes.
作者信息
Minder E, Paumgartner G
出版信息
Experientia. 1979 Jul 15;35(7):888-90. doi: 10.1007/BF01955131.
PMID:477843
Abstract
Uptake of both taurocholate and indocyanine green (ICG) by isolated rat hepatocytes was saturable and obeyed Michaelis-Menten kinetics. Only uptake of taurocholate exhibited Na+-dependence, a phenomenon compatible with active membrane transport. These findings suggest that the mechanisms responsible for hepatocellular uptake of bile acids and anionic dyes differ fundamentally.
摘要
分离的大鼠肝细胞对牛磺胆酸盐和吲哚菁绿（ICG）的摄取均具有饱和性，并符合米氏动力学。只有牛磺胆酸盐的摄取表现出Na⁺依赖性，这一现象与主动膜转运相符。这些发现表明，负责肝细胞摄取胆汁酸和阴离子染料的机制在根本上有所不同。
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