精神分裂症和卟啉症的“淡紫色因子”，即5-羟基血卟啉内酰胺，对豚鼠回肠的药理活性较低。
The 'mauve factor' of schizophrenia and porphyria, 5-hydroxyhaemopyrrole lactam, has low pharmacological potency on guinea-pig ileum.
作者信息
Gorchein A, Rogers A T
出版信息
Experientia. 1979 Aug 15;35(8):1078-9. doi: 10.1007/BF01949952.
PMID:477885
Abstract
5-Hydroxyhaemopyrrole lactam, the 'mauve factor' reported in the urine of schizophrenics and porphyrics was found to inhibit electrically-stimulated contractions of guinea-pig ileum only at high concentrations (ID50 = 8.5 mM). This low potency makes it unlikely that the compound can account for neurotoxic effects in human porphyria.
摘要
5-羟基血卟啉内酰胺，即曾在精神分裂症患者及卟啉症患者尿液中被报道的“淡紫色因子”，仅在高浓度时（半数抑制浓度 = 8.5毫摩尔）才会抑制豚鼠回肠的电刺激收缩。这种低效性使得该化合物不太可能是人类卟啉症中神经毒性作用的原因。
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