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丙磺舒对小鼠血浆氯胺酮水平的影响。

Alteration of plasma ketamine levels in mice by probenecid.

作者信息

Davisson J N

出版信息

Experientia. 1979 Aug 15;35(8):1079-81. doi: 10.1007/BF01949953.

DOI:10.1007/BF01949953
PMID:477886
Abstract

Probenecid increases plasma ketamine levels in mice concurrently with an enhancement of duration of loss of righting reflex. The magnitude of these changes is directly related to the dose of ketamine and intervals between administration of compounds. Plasma levels of anesthetic are similar for all animals upon termination of hypnosis.

摘要

丙磺舒可提高小鼠血浆中的氯胺酮水平，同时延长翻正反射消失的持续时间。这些变化的程度与氯胺酮的剂量以及两种化合物给药的间隔时间直接相关。催眠结束时，所有动物的麻醉剂血浆水平相似。

相似文献

1
Alteration of plasma ketamine levels in mice by probenecid.丙磺舒对小鼠血浆氯胺酮水平的影响。
Experientia. 1979 Aug 15;35(8):1079-81. doi: 10.1007/BF01949953.
2
Potentiation of barbiturate- and halothane-induced hypnosis after probenecid or sulfinpyrazone pretreatment.丙磺舒或磺吡酮预处理后巴比妥酸盐和氟烷诱导的催眠作用增强。
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3
Potency of propofol, thiopentone and ketamine at various endpoints in New Zealand White rabbits.
Lab Anim. 2000 Jan;34(1):36-45. doi: 10.1258/002367700780578037.
4
Anesthetic effects and body weight changes associated with ketamine-xylazine-lidocaine administered to CD-1 mice.氯胺酮-赛拉嗪-利多卡因对CD-1小鼠的麻醉效果及体重变化
PLoS One. 2017 Sep 14;12(9):e0184911. doi: 10.1371/journal.pone.0184911. eCollection 2017.
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Ketamine-induced anesthesia involves the N-methyl-D-aspartate receptor-channel complex in mice.
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Ketamine/xylazine/butorphanol: a new anesthetic combination for rabbits.氯胺酮/赛拉嗪/布托啡诺：一种用于兔子的新型麻醉合剂。
Lab Anim Sci. 1992 Feb;42(1):57-62.
7
Biodisposition of ketamine in the rat: self-induction of metabolism.
J Pharmacol Exp Ther. 1976 Mar;196(3):536-44.
8
The effect of delta9-tetrahydrocannabinol pretreatment on ketamine thiopental or CT-1341--induced loss of righting reflex in mice.δ9-四氢大麻酚预处理对氯胺酮、硫喷妥钠或CT-1341诱导的小鼠翻正反射消失的影响。
Arch Int Pharmacodyn Ther. 1974 Feb;207(2):270-81.
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Effect of three types of mixed anesthetic agents alternate to ketamine in mice.三种混合麻醉剂替代氯胺酮对小鼠的影响。
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Mutation of alpha1G T-type calcium channels in mice does not change anesthetic requirements for loss of the righting reflex and minimum alveolar concentration but delays the onset of anesthetic induction.小鼠中α1G T型钙通道的突变不会改变翻正反射消失和最低肺泡浓度的麻醉需求，但会延迟麻醉诱导的开始。
Anesthesiology. 2007 Jun;106(6):1177-85. doi: 10.1097/01.anes.0000267601.09764.e6.

本文引用的文献

1
KINETICS OF DRUG METABOLISM BY HEPATIC MICROSOMES.
Biochem Pharmacol. 1964 Jul;13:1007-16. doi: 10.1016/0006-2952(64)90097-8.
2
On the mechanism of action of probenecid on renal tubular secretion.关于丙磺舒对肾小管分泌的作用机制。
Bull Johns Hopkins Hosp. 1960 Jun;106:333-46.
3
Application of seady-state kinetics to studies of the transfer of 5-hydroxyindoleacetic acid from brain to plasma.稳态动力学在5-羟色胺酸从脑到血浆转运研究中的应用。
J Pharmacol Exp Ther. 1967 Nov;158(2):214-8.
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Active transport of chlorothiazide into bile.氯噻嗪向胆汁的主动转运。
Am J Physiol. 1966 Sep;211(3):643-6. doi: 10.1152/ajplegacy.1966.211.3.643.
5
Biliary excretion of probenecid and its glucuronide.丙磺舒及其葡糖醛酸苷的胆汁排泄。
J Pharmacol Exp Ther. 1968 Dec;164(2):387-95.
6
Influence of enzyme induction on the sleeping time of rats.酶诱导对大鼠睡眠时间的影响。
Can Anaesth Soc J. 1969 Nov;16(6):538-46. doi: 10.1007/BF03004547.
7
Metabolites of probenecid. Chemical, physical, and pharmacological studies.丙磺舒的代谢产物。化学、物理及药理学研究。
J Med Chem. 1972 Jul;15(7):709-13. doi: 10.1021/jm00277a004.
8
Enhancement and inhibition of drug metabolism.药物代谢的增强与抑制
Annu Rev Pharmacol. 1971;11:37-56. doi: 10.1146/annurev.pa.11.040171.000345.
9
On the cerebral accumulation of ketamine and the relationship between metabolism of the drug and its pharmacological effects.关于氯胺酮在大脑中的蓄积及其药物代谢与药理作用之间的关系。
J Pharmacol Exp Ther. 1974 May;189(2):351-8.
10
Biodisposition of ketamine in the rat: self-induction of metabolism.
J Pharmacol Exp Ther. 1976 Mar;196(3):536-44.