[以豚鼠乳头作为黄褐斑研究模型（作者译）]
[Guinea pig nipple as a model for the investigation of melasma (author's transl)].
作者信息
Brun R, Laugier P
出版信息
Dermatologica. 1979;159(3):210-6.
PMID:478059
Abstract
The nipples of male tan guinea pigs were used to test the effects on the skin of oral contraceptive pills and drugs. The daily topically applied doses were 1/2,000 of a pill. After 3 weeks, the nipples treated with solutions of ethinyloestradiol-containing pills had grown (200-300%), the epidermis showed acanthosis (150-250%) and strong hyperpigmentation. Mestranol-containing pills as well as pure progestogen substances did not produce these effects.
摘要
雄性棕豚鼠的乳头被用于测试口服避孕药和药物对皮肤的影响。每日局部涂抹剂量为一片药的1/2000。3周后，用含炔雌醇的药丸溶液处理的乳头增大（200 - 300%），表皮出现棘皮症（150 - 250%）和明显的色素沉着。含炔诺醚的药丸以及纯孕激素物质未产生这些影响。
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