Villaume C, Beck B, Debry G
Diabete Metab. 1979 Jun;5(2):159-65.
Substances which react with anti-insulin antibodies, but have a higher molecular weight than insulin are described. They have been studied by various authors in pancreatic adenomas, pancreas extracts, serum and cell-free systems. Proinsulin was the first of these products to be discovered, followed by its precursor, pre-proinsulin, and subsequently by a whole series of substances of ill-defined composition and more or less similar properties, grouped under the heading of "high molecular weight immunoreactive insulin" (HWIRI).
已描述了与抗胰岛素抗体发生反应但分子量高于胰岛素的物质。多位作者对其在胰腺腺瘤、胰腺提取物、血清及无细胞体系中进行了研究。胰岛素原是这些产物中首个被发现的，随后是其前体——前胰岛素原，接着又发现了一系列组成不明且性质或多或少相似的物质，它们被归类于“高分子量免疫反应性胰岛素”（HWIRI）这一标题下。
