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The metabolism of tamoxifen (I.C.I. 46,474). II. In female patients.

作者信息

Fromson J M, Pearson S, Bramah S

出版信息

Xenobiotica. 1973 Nov;3(11):711-4. doi: 10.3109/00498257309151595.

DOI:10.3109/00498257309151595
PMID:4783632
Abstract
摘要

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引用本文的文献

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Pharmacokinetics of Tamoxifen and Its Major Metabolites and the Effect of the African Ancestry Specific CYP2D6*17 Variant on the Formation of the Active Metabolite, Endoxifen.他莫昔芬及其主要代谢产物的药代动力学以及非洲裔特异性CYP2D6*17变体对活性代谢产物4-羟基他莫昔芬形成的影响。
J Pers Med. 2023 Jan 31;13(2):272. doi: 10.3390/jpm13020272.
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50th anniversary of the first clinical trial with ICI 46,474 (tamoxifen): then what happened?ICI 46,474(他莫昔芬)首次临床试验 50 周年:那么后来发生了什么?
Endocr Relat Cancer. 2021 Jan;28(1):R11-R30. doi: 10.1530/ERC-20-0335.
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Oxidative stress contributes to the tamoxifen-induced killing of breast cancer cells: implications for tamoxifen therapy and resistance.
氧化应激促进他莫昔芬诱导的乳腺癌细胞杀伤:对他莫昔芬治疗及耐药性的影响
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Endocr Relat Cancer. 2014 May 6;21(3):R235-46. doi: 10.1530/ERC-14-0092. Print 2014 Jun.
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Physiologically Based Pharmacokinetic Modeling of Tamoxifen and its Metabolites in Women of Different CYP2D6 Phenotypes Provides New Insight into the Tamoxifen Mass Balance.不同CYP2D6表型女性中他莫昔芬及其代谢物的生理药代动力学建模为他莫昔芬质量平衡提供了新的见解。
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Mass balance studies, with a focus on anticancer drugs.以抗癌药物为重点的质量平衡研究。
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