Roy S, Datta J K
Horm Res. 1979;11(2):61-8. doi: 10.1159/000179041.
Daily administration of 100 micrograms of testosterone to unilaterally ovariectomized rats for 18 days caused a significant decrease in compensatory ovarian hypertrophy. The number of corpora lutea was markedly reduced and many cystic follicles were noticeable. Administration of graded doses (0.5, 1 and 3 mg daily) of flutamide over the same period did not cause any significant change in the weight and histology of the ovary in untreated unilaterally ovariectomized animals. However, treatment with the same doses of flutamide prevented the changes observed in the reamining ovary of testosterone-treated animals.
对单侧卵巢切除的大鼠每日给予100微克睾酮，持续18天，可导致代偿性卵巢肥大显著减轻。黄体数量明显减少，许多囊性卵泡可见。同期对未处理的单侧卵巢切除动物给予分级剂量（每日0.5、1和3毫克）的氟他胺，未引起卵巢重量和组织学的任何显著变化。然而，用相同剂量的氟他胺进行治疗可防止在接受睾酮治疗的动物的对侧卵巢中观察到的变化。
