通过大鼠慢性降钙素缺乏评估降钙素的生理作用。

The psysiological role of calcitonin assessed through chronic calcitonin deficiency in rats.

Kumar M A, Sturtridge W C

J Physiol. 1973 Aug;233(1):33-43. doi: 10.1113/jphysiol.1973.sp010295.

Abstract

An attempt was made to assess the physiological role of calcitonin by producing its prolonged deficiency in rats.2. Three groups of young rats viz. (I) sham-operated controls, (II) thyroidectomized with thyroxine replacement and (III) thyroidectomized with thyroxine as well as calcitonin replacement, all with parathyroid autografts, were studied for 5 weeks. Groups II and III showed impaired Ca tolerance and group II also showed significant reduction in total (organic and inorganic) mass of femora as compared to group I.3. Three similar groups of old mature rats were studied as under (2) for 9 weeks. Groups II and III in this case showed no significant changes as compared to group I.4. In intact mature rats, Ca tolerance is impaired, thyroid content of calcitonin is high and the hypocalcaemic action of calcitonin is much reduced as compared to intact young rats.5. It is concluded that calcitonin plays a useful but non-essential role in Ca metabolism and bone development of young growing rats. Its function, if any, in mature rats on a normal diet remains doubtful.

摘要

通过使大鼠长期缺乏降钙素，来尝试评估其生理作用。
研究了三组幼鼠，即：（I）假手术对照组，（II）甲状腺切除并用甲状腺素替代的大鼠，以及（III）甲状腺切除并用甲状腺素和降钙素替代的大鼠，所有大鼠均进行了甲状旁腺自体移植，研究时长为5周。与第一组相比，第二组和第三组表现出钙耐受性受损，且第二组的股骨总质量（有机和无机）也显著降低。
对三组类似的老龄成熟大鼠按照（2）中的方法进行了9周的研究。在这种情况下，与第一组相比，第二组和第三组未显示出显著变化。
在完整的成熟大鼠中，与完整的幼鼠相比，钙耐受性受损，甲状腺降钙素含量较高，且降钙素的降钙作用大大降低。
得出的结论是，降钙素在幼龄生长大鼠的钙代谢和骨骼发育中发挥着有益但非必需的作用。其在正常饮食的成熟大鼠中的功能（如果有的话）仍存疑问。