发育过程中大鼠肝脏和大脑中胱硫醚酶活性的研究。体内激素和氨基酸的影响。
Studies on cystathionase activity in rat liver and brain during development. Effects of hormones and amino acids in vivo.
作者信息
Heinonen K
出版信息
Biochem J. 1973 Dec;136(4):1011-5. doi: 10.1042/bj1361011.
Abstract
High activity of cystathionase was present in rat liver but only low amounts of activity in rat brain during development. Triamcinolone had no effect on liver cystathionase activity in foetuses but increased the enzyme activity significantly in postnatal rats. l-Thyroxine decreased liver cystathionase activity significantly in newborn rats; administration of pyridoxal 5'-phosphate did not prevent this effect. l-Methionine significantly increased liver cystathionase activity in newborn rats.
摘要
在发育过程中，大鼠肝脏中胱硫醚酶活性较高，而大鼠大脑中的活性较低。曲安西龙对胎儿肝脏中的胱硫醚酶活性没有影响，但能显著提高出生后大鼠的该酶活性。左旋甲状腺素能显著降低新生大鼠肝脏中的胱硫醚酶活性；给予5'-磷酸吡哆醛并不能阻止这种作用。左旋甲硫氨酸能显著提高新生大鼠肝脏中的胱硫醚酶活性。
相似文献
1
Studies on cystathionase activity in rat liver and brain during development. Effects of hormones and amino acids in vivo.发育过程中大鼠肝脏和大脑中胱硫醚酶活性的研究。体内激素和氨基酸的影响。
Biochem J. 1973 Dec;136(4):1011-5. doi: 10.1042/bj1361011.
2
Effects of several unusual sulfur-containing amino acids on rat liver cystathionine-gamma-lyase.几种特殊含硫氨基酸对大鼠肝脏胱硫醚-γ-裂解酶的影响。
Physiol Chem Phys. 1975;7(5):401-8.
3
Studies on the inactivation of rat liver cystathionase.大鼠肝脏胱硫醚酶失活的研究。
Enzyme. 1974;18(5):262-70. doi: 10.1159/000459435.
4
Effects of hypo- and hyperthyroidism on the activity of cystathionase in mammalian parenchymatous organs during early development.甲状腺功能减退和亢进对哺乳动物实质器官在早期发育过程中胱硫醚酶活性的影响。
Experientia. 1977 Nov 15;33(11):1427-8. doi: 10.1007/BF01918784.
5
gamma-Cystathionase of rat liver: effects of pyridoxal phosphate and other compounds on reaction rates.
Arch Biochem Biophys. 1975 Dec;171(2):378-84. doi: 10.1016/0003-9861(75)90046-6.
6
Binding of pyridoxal 5-phosphate to cystathionase.磷酸吡哆醛与胱硫醚酶的结合。
J Biol Chem. 1973 Nov 10;248(21):7370-5.
7
Functional arginine in the active center of rat liver cystathionase.
FEBS Lett. 1977 Sep 15;81(2):335-8. doi: 10.1016/0014-5793(77)80548-6.
8
Pyridoxal 5'phosphate binding site of Escherichia coli beta cystathionase and cystathionine gamma synthase comparison of their sequences.大肠杆菌β-胱硫醚酶的磷酸吡哆醛5'-磷酸结合位点与胱硫醚γ-合酶的序列比较
Biochem Biophys Res Commun. 1987 Sep 15;147(2):565-71. doi: 10.1016/0006-291x(87)90968-5.
9
Role of the transsulfuration pathway and of gamma-cystathionase activity in the formation of cysteine and sulfate from methionine in rat hepatocytes.转硫途径及γ-胱硫醚酶活性在大鼠肝细胞中由蛋氨酸形成半胱氨酸和硫酸盐过程中的作用。
J Nutr. 1990 Aug;120(8):837-45. doi: 10.1093/jn/120.8.837.
10
Effect of ethionine on gamma-cystathionase, homoserine dehydratase and cysteine desulfhydrase activities.
Arch Int Physiol Biochim. 1979 Feb;87(1):105-8. doi: 10.3109/13813457909070490.
引用本文的文献
1
Role of Hydrogen Sulfide in the Endocrine System.硫化氢在内分泌系统中的作用。
Front Endocrinol (Lausanne). 2021 Jul 16;12:704620. doi: 10.3389/fendo.2021.704620. eCollection 2021.
2
Identification of altered brain metabolites associated with TNAP activity in a mouse model of hypophosphatasia using untargeted NMR-based metabolomics analysis.使用基于非靶向核磁共振的代谢组学分析，在低磷酸酯酶症小鼠模型中鉴定与组织非特异性碱性磷酸酶（TNAP）活性相关的脑代谢物变化。
J Neurochem. 2017 Mar;140(6):919-940. doi: 10.1111/jnc.13950.
3
H2 S modulates duodenal motility in male rats via activating TRPV1 and K(ATP) channels.H2S 通过激活 TRPV1 和 K(ATP)通道调节雄性大鼠的十二指肠运动。
Br J Pharmacol. 2014 Mar;171(6):1534-50. doi: 10.1111/bph.12562.
4
High fat diet-induced non alcoholic fatty liver disease in rats is associated with hyperhomocysteinemia caused by down regulation of the transsulphuration pathway.高脂饮食诱导的大鼠非酒精性脂肪性肝病与转硫途径下调导致的高同型半胱氨酸血症有关。
Lipids Health Dis. 2011 Apr 19;10:60. doi: 10.1186/1476-511X-10-60.
5
Metabolic and genomic response to dietary isocaloric protein restriction in the rat.大鼠对饮食等热量蛋白质限制的代谢和基因组反应。
J Biol Chem. 2011 Feb 18;286(7):5266-77. doi: 10.1074/jbc.M110.185991. Epub 2010 Dec 8.
6
H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase.硫化氢作为一种生理性血管舒张剂：胱硫醚γ-裂解酶缺失小鼠的高血压
Science. 2008 Oct 24;322(5901):587-90. doi: 10.1126/science.1162667.
7
Murine cystathionine gamma-lyase: complete cDNA and genomic sequences, promoter activity, tissue distribution and developmental expression.小鼠胱硫醚γ-裂解酶：完整的cDNA和基因组序列、启动子活性、组织分布及发育表达
Biochem J. 2004 Jul 1;381(Pt 1):113-23. doi: 10.1042/BJ20040243.
8
Inhibition of liver trans-sulphuration pathway by propargylglycine mimics gene expression changes found in the mammary gland of weaned lactating rats: role of glutathione.炔丙基甘氨酸对肝脏转硫途径的抑制模拟了断奶泌乳大鼠乳腺中发现的基因表达变化：谷胱甘肽的作用。
Biochem J. 2003 Aug 1;373(Pt 3):825-34. doi: 10.1042/BJ20030387.
9
Human cystathionine gamma-lyase: developmental and in vitro expression of two isoforms.人胱硫醚γ-裂解酶：两种同工型的发育及体外表达
Biochem J. 2000 Apr 1;347 Pt 1(Pt 1):291-5.
10
Cystathionase activity and glutathione metabolism in redifferentiating rat hepatocyte primary cultures.再分化大鼠肝细胞原代培养物中的胱硫醚酶活性与谷胱甘肽代谢
Cell Biol Toxicol. 1987 Dec;3(4):361-77. doi: 10.1007/BF00119910.
本文引用的文献
1
Factors influencing the development of urea-synthesizing enzymes in rat liver.影响大鼠肝脏中尿素合成酶发育的因素。
Biochem J. 1968 May;107(6):793-7. doi: 10.1042/bj1070793.
2
Development of gluconeogenesis in neonatal rat liver. Effect of triamcinolone.新生大鼠肝糖异生的发育。曲安奈德的影响。
Biochem J. 1967 Dec;105(3):1219-27. doi: 10.1042/bj1051219.
3
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
4
5
DITHIOTHREITOL, A NEW PROTECTIVE REAGENT FOR SH GROUPS.二硫苏糖醇，一种新的巯基保护剂。
Biochemistry. 1964 Apr;3:480-2. doi: 10.1021/bi00892a002.
6
EFFECT OF DL-ETHIONINE ON THE LEVEL OF CYSTATHIONASE IN RAT LIVER.
Nature. 1963 Oct 5;200:75. doi: 10.1038/200075a0.
7
[Thyroid hormones and desulfuration enzymes of L-cysteine in the rat liver].[大鼠肝脏中的甲状腺激素与L-半胱氨酸脱硫酶]
Biochim Biophys Acta. 1962 Jun 4;59:744-6. doi: 10.1016/0006-3002(62)90667-4.
8
Sulfurylation of estrogens by the human fetus.人类胎儿对雌激素的硫酸化作用。
Endocrinology. 1961 May;68:825-30. doi: 10.1210/endo-68-5-825.
9
Pyridoxine and pyridoxal phosphate concentrations in the liver and heart of thyroxinized animals.
Experientia. 1959 Jun 15;15(6):229-30. doi: 10.1007/BF02158122.
10
Specificity of the adaptive response to tyrosine-alpha-ketoglutarate transaminase in the rat.大鼠对酪氨酸-α-酮戊二酸转氨酶适应性反应的特异性
J Biol Chem. 1958 Nov;233(5):1186-9.
Zotero 插件