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相似文献

1
A model for the passage of the nurohypophysial hormones and their related proteins through the rat neurohypophysis.神经垂体激素及其相关蛋白通过大鼠神经垂体的转运模型。
Biochem J. 1973 Dec;136(4):1053-8. doi: 10.1042/bj1361053.
2
Intra-axonal transport and turnover of neurophysins in the rat. A proposal for a possible origin of the minor neurophysin component.大鼠中神经垂体素的轴突内运输与更新。关于次要神经垂体素成分可能来源的一项提议。
Biochem J. 1973 Dec;136(4):1047-52. doi: 10.1042/bj1361047.
3
Oxytocin, vasopressin and neurophysins in the hypothalamo-neurohypophysial system of the human fetus.人类胎儿下丘脑 - 神经垂体系统中的催产素、加压素和神经垂体素
J Endocrinol. 1982 Dec;95(3):403-8. doi: 10.1677/joe.0.0950403.
4
Levels of neurohypophyseal peptides in the rat during the first month of life. II. Response to physiological stimuli.大鼠出生后第一个月神经垂体肽的水平。II. 对生理刺激的反应。
Endocrinology. 1980 Sep;107(3):755-60. doi: 10.1210/endo-107-3-755.
5
Tentative identification of a vasopressin-neurophysin and an oxytocin-neurophysin in the rat.大鼠中血管升压素-神经垂体素和催产素-神经垂体素的初步鉴定。
Biochem J. 1971 Oct;124(4):809-13. doi: 10.1042/bj1240809.
6
Neurophysin in the brain and pituitary gland of normal and scrapie-affected sheep--I. Its localization in the hypothalamus and neurohypophysis with particular reference to a new hypothalamic neurosecretory pathway to the median eminence.正常及患羊瘙痒病绵羊大脑和垂体中的神经垂体素——I. 其在下丘脑和神经垂体的定位，特别涉及一条通向正中隆起的新的下丘脑神经分泌途径。
Neuroscience. 1976 Aug;1(4):275-99. doi: 10.1016/0306-4522(76)90056-7.
7
Movement of neurosecretory product through the anatomical compartments of the neural lobe of the pituitary gland. An electron microscopic autoradiographic study.神经分泌产物在垂体神经叶解剖分区中的移动。一项电子显微镜放射自显影研究。
Cell Tissue Res. 1975;156(4):483-97. doi: 10.1007/BF00225108.
8
[Ultrastructural localization of neurohypophyseal hormones and their carrier proteins by the "triple bridge" immunoenzymatic technique].[应用“双桥”免疫酶技术对神经垂体激素及其载体蛋白进行超微结构定位]
C R Seances Soc Biol Fil. 1977;171(4):914-8.
9
Proceedings: Subcellular studies of the incorporation of (35S)cysteine into components of the neurohypophysis.论文集：（35S）半胱氨酸掺入神经垂体成分的亚细胞研究
J Endocrinol. 1974 May;61(2):LVI-LVII.
10
Neurohypophyseal peptides in the developing rat fetus.发育中大鼠胎儿的神经垂体肽
Brain Res. 1980 Aug 11;195(1):177-86. doi: 10.1016/0006-8993(80)90875-6.

引用本文的文献

1
Spike triggered hormone secretion in vasopressin cells; a model investigation of mechanism and heterogeneous population function.棘波触发神经垂体加压素细胞分泌；对机制和异质群体功能的模型研究。
PLoS Comput Biol. 2013;9(8):e1003187. doi: 10.1371/journal.pcbi.1003187. Epub 2013 Aug 15.
2
Discharge of gonadotrophin-releasing hormone from the mediobasal part of the hypothalamus: effect of stimulation frequency and gonadal steroids.
Exp Brain Res. 1980;39(4):453-60. doi: 10.1007/BF00239310.
3
Factors governing the periodic activation of supraoptic and paraventricular neurosecretory cells during suckling in the rat.大鼠哺乳期间视上核和室旁核神经分泌细胞周期性激活的调控因素。
J Physiol. 1975 Sep;250(2):443-61. doi: 10.1113/jphysiol.1975.sp011064.
4
Movement of neurosecretory product through the anatomical compartments of the neural lobe of the pituitary gland. An electron microscopic autoradiographic study.神经分泌产物在垂体神经叶解剖分区中的移动。一项电子显微镜放射自显影研究。
Cell Tissue Res. 1975;156(4):483-97. doi: 10.1007/BF00225108.
5
Granulolysis in neurosecretory neurons of the rat supraoptico-posthypophyseal system.大鼠视上核 - 垂体后叶系统神经分泌神经元中的颗粒溶解
Cell Tissue Res. 1976 Sep 6;172(1):39-58. doi: 10.1007/BF00226048.

本文引用的文献

1
Capacity of the neurohypophysis to release vasopressin.神经垂体释放抗利尿激素的能力。
Endocrinology. 1967 Oct;81(4):755-70. doi: 10.1210/endo-81-4-755.
2
In vitro studies of the release mechanism for vasopressin in rats.大鼠体内血管加压素释放机制的体外研究。
Acta Endocrinol (Copenh). 1966 Dec;53(4):644-54. doi: 10.1530/acta.0.0530644.
3
Further studies on the capacity of the neurohypophysis to release vasopressin.关于神经垂体释放抗利尿激素能力的进一步研究。
Endocrinology. 1968 Aug;83(2):251-62. doi: 10.1210/endo-83-2-251.
4
Tentative identification of a vasopressin-neurophysin and an oxytocin-neurophysin in the rat.大鼠中血管升压素-神经垂体素和催产素-神经垂体素的初步鉴定。
Biochem J. 1971 Oct;124(4):809-13. doi: 10.1042/bj1240809.
5
Biosynthesis and release of vasopressin and neurophysin.血管加压素和神经垂体素的生物合成与释放。
Recent Prog Horm Res. 1969;25:447-91. doi: 10.1016/b978-0-12-571125-8.50013-2.
6
Intra-axonal transport and turnover of neurophysins in the rat. A proposal for a possible origin of the minor neurophysin component.大鼠中神经垂体素的轴突内运输与更新。关于次要神经垂体素成分可能来源的一项提议。
Biochem J. 1973 Dec;136(4):1047-52. doi: 10.1042/bj1361047.
7
Intra-axonal transport and turnover of neurohypophysial hormones in the rat.大鼠神经垂体激素的轴突内运输与更新
J Physiol. 1972 Dec;227(2):553-64. doi: 10.1113/jphysiol.1972.sp010047.
8
Transport and turnover of neurohypophysial proteins of the rat.大鼠神经垂体蛋白的转运与更新
J Neurochem. 1971 Nov;18(11):2007-16. doi: 10.1111/j.1471-4159.1971.tb05060.x.

神经垂体激素及其相关蛋白通过大鼠神经垂体的转运模型。

A model for the passage of the nurohypophysial hormones and their related proteins through the rat neurohypophysis.

作者信息

Burford G D, Clifford P, Jones C W, Pickring B T

出版信息

Biochem J. 1973 Dec;136(4):1053-8. doi: 10.1042/bj1361053.

DOI:10.1042/bj1361053
PMID:4786527
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1166056/
Abstract

The change in the radioactivity of vasopressin-neurophysin in the rat neurohypophysis after an intracisternal injection of [(35)S]cysteine was fitted to several mathematical models. The data fitted best a model in which there is a linear input of radioactive protein into one pool of the neurohypophysis, from which it is either released by an exponential process or transferred to a second pool from which it is released by a second exponential process with a rate constant much lower than the first. This model is compatible with the existence of a ;readily releasable' pool first postulated by Sachs et al. (1967). Data for the change in radioactivity of vasopressin also gave a good fit in this model. Calculation of the rate constants suggested that the first pool represented about 2% of the total hormone.

摘要

在大鼠脑池内注射[(35)S]半胱氨酸后，对大鼠神经垂体中血管升压素-神经垂体素放射性的变化进行了几种数学模型拟合。数据最符合的模型是：放射性蛋白质以线性方式输入神经垂体的一个池，该池中放射性蛋白质要么通过指数过程释放，要么转移到第二个池，从第二个池中以比第一个池低得多的速率常数通过第二个指数过程释放。该模型与萨克斯等人（1967年）首次提出的“易于释放”池的存在相一致。血管升压素放射性变化的数据在该模型中也拟合得很好。速率常数的计算表明，第一个池约占总激素的2%。