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相似文献

1
Anti-inflammatory and some other pharmacological effects of 3,4-trans-2,2-dimethyl-3-phenyl-4-(p-(beta-pyrrolidinoethoxy)-phenyl)-7-methoxy-chroman (Centchroman).3,4-反式-2,2-二甲基-3-苯基-4-(对-(β-吡咯烷基乙氧基)-苯基)-7-甲氧基色满（苯并色满）的抗炎及其他药理作用
Br J Pharmacol. 1973 Sep;49(1):64-73. doi: 10.1111/j.1476-5381.1973.tb08268.x.
2
Effect of 3,4-trans-2,2-dimethyl-3-phenyl-4-P-(beta-pyrrolidinoethoxy) phenyl -7-methoxy chroman (centchroman) on the biochemistry of the fallopian tube and uterus of rhesus monkeys (Macaca mulatta).3,4-反式-2,2-二甲基-3-苯基-4-P-(β-吡咯烷基乙氧基)苯基-7-甲氧基色满（醋炔诺酮）对恒河猴（猕猴）输卵管和子宫生物化学的影响。
Contraception. 1975 Mar;11(3):309-16. doi: 10.1016/0010-7824(75)90039-6.
3
Pharmacological studies of the new antiinflammatory agent 3-formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-o ne. 1st communication: antiinflammatory, analgesic and other related properties.新型抗炎药3-甲酰氨基-7-甲基磺酰氨基-6-苯氧基-4H-1-苯并吡喃-4-酮的药理学研究。首次通讯：抗炎、镇痛及其他相关性质。
Arzneimittelforschung. 1992 Jul;42(7):935-44.
4
Pharmacological study on a new analgesic-anti-inflammatory drug: alpha-(4-(1-oxo-2-iso-indolinyl)-phenyl)-propionic acid of K 4277.一种新型镇痛抗炎药K 4277（α-（4-（1-氧代-2-异吲哚啉基）-苯基）-丙酸）的药理学研究
Arzneimittelforschung. 1973 Aug;23(8):1100-7.
5
Pharmacological properties of the anti-inflammatory agent pyridyl-biphenylyl-acetamide (diphenpyramide).抗炎药吡啶基 - 联苯基 - 乙酰胺（二苯吡胺）的药理特性。
Arzneimittelforschung. 1977;27(11):2086-93.
6
Mode of action of a new non-steroidal post-coital antifertility agent (centchroman: 67/20 CDRI) in rats.一种新型非甾体性交后抗生育剂（色满卡林：67/20 CDRI）在大鼠体内的作用方式。
Contraception. 1974 Mar;9(3):279-89. doi: 10.1016/0010-7824(74)90019-5.
7
Nature of estrogenic and anti-estrogenic actions of centchroman on rat uterus.色满卡林对大鼠子宫的雌激素和抗雌激素作用性质
Contraception. 1976 May;13(5):597-604. doi: 10.1016/0010-7824(76)90015-9.
8
Anti-inflammatory activity of an imidazopyridine derivative (miroprofen).一种咪唑并吡啶衍生物（米洛芬）的抗炎活性。
Arzneimittelforschung. 1981;31(7):1111-8.
9
Pharmacological activity and toxicity of apyramide: comparison with non-steroidal anti-inflammatory agents.阿吡胺的药理活性与毒性：与非甾体抗炎药的比较。
Drugs Exp Clin Res. 1987;13(5):247-52.
10
Pharmacological study of a new non-steroidal anti-inflammatory drug: protacine (CR 604).一种新型非甾体抗炎药：普罗他辛（CR 604）的药理学研究
Arzneimittelforschung. 1979;29(8):1116-22.

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1
Beyond muscles: The untapped potential of creatine.超越肌肉：肌酸的未开发潜力。
Int Immunopharmacol. 2016 Aug;37:31-42. doi: 10.1016/j.intimp.2015.12.034. Epub 2016 Jan 8.
2
Nuclear receptors and their selective pharmacologic modulators.核受体及其选择性药理调节剂。
Pharmacol Rev. 2013 Mar 1;65(2):710-78. doi: 10.1124/pr.112.006833. Print 2013 Apr.
3
Absorption of hydrocortisone acetate in human connective tissue using phonophoresis.声透法在人体结缔组织中醋酸氢化可的松的吸收。
Sports Health. 2011 Jul;3(4):346-51. doi: 10.1177/1941738111405970.
4
Prostanoid mediated effects of centchroman, a non-steroidal oral contraceptive.色满炔诺酮（一种非甾体口服避孕药）的前列腺素介导效应。
Agents Actions. 1986 Aug;18(5-6):596-9. doi: 10.1007/BF01964969.
5
Biological activity of some Schiff bases and their metal complexes.一些席夫碱及其金属配合物的生物活性。
Biol Trace Elem Res. 1989;23:145-50. doi: 10.1007/BF02917185.
6
Prostaglandins, nonsteroidal anti-inflammatory agents and eye disease.前列腺素、非甾体抗炎药与眼病
Trans Am Ophthalmol Soc. 1976;74:637-60.

本文引用的文献

1
Mortality of adrenalectomized young rats, with improved technique of operation, and after a period of treatment with cortical hormone.采用改良手术技术并经一段时间皮质激素治疗后，肾上腺切除的幼鼠死亡率。
J Physiol. 1935 Apr 26;84(1):70-82.1. doi: 10.1113/jphysiol.1935.sp003257.
2
Further studies concerning the participation of the adrenal cortex in the pathogenesis of arthritis.关于肾上腺皮质在关节炎发病机制中的作用的进一步研究。
Br Med J. 1949 Nov 19;2(4637):1129-35, illust. doi: 10.1136/bmj.2.4637.1129.
3
Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs.角叉菜胶诱导大鼠后爪水肿作为抗炎药物的一种测定方法。
Proc Soc Exp Biol Med. 1962 Dec;111:544-7. doi: 10.3181/00379727-111-27849.
4
Ability of some antirheumatic drugs to uncouple oxidative phosphorylation.某些抗风湿药物解偶联氧化磷酸化的能力。
Nature. 1962 Dec 29;196:1323-4. doi: 10.1038/1961323a0.
5
A modified plethysmographic apparatus for recording volume changes in the rat paw.一种用于记录大鼠爪部容积变化的改良体积描记仪。
J Pharm Pharmacol. 1962 Jul;14:464-6. doi: 10.1111/j.2042-7158.1962.tb11125.x.
6
Analgesic properties of 4-ethoxycarbonyl-1-(2-hydroxy-3-phenoxypropyl) 4-phenylpiperidine (B.D.H. 20) and some related compounds.4-乙氧羰基-1-(2-羟基-3-苯氧基丙基)4-苯基哌啶（B.D.H. 20）及一些相关化合物的镇痛特性
J Pharm Pharmacol. 1960 Aug;12:449-59. doi: 10.1111/j.2042-7158.1960.tb12692.x.
7
Analgesic antipyretic drugs as antagonists of bradykinin.作为缓激肽拮抗剂的解热镇痛药。
Br J Pharmacol Chemother. 1960 Dec;15(4):601-10. doi: 10.1111/j.1476-5381.1960.tb00288.x.
8
Effect of alterations in side chain upon anti-inflammatory and liver glycogen activities of hydrocortisone esters.侧链改变对氢化可的松酯抗炎及肝糖原活性的影响。
J Am Pharm Assoc Am Pharm Assoc. 1957 Sep;46(9):515-9. doi: 10.1002/jps.3030460902.
9
A new method for the direct determination of serum cholesterol.一种直接测定血清胆固醇的新方法。
J Lab Clin Med. 1953 Mar;41(3):486-92.
10
Carrageenan paw edema in the mouse.角叉菜胶诱导的小鼠爪肿胀
Life Sci. 1969 Jun 1;8(11):601-6. doi: 10.1016/0024-3205(69)90021-6.

3,4-反式-2,2-二甲基-3-苯基-4-(对-(β-吡咯烷基乙氧基)-苯基)-7-甲氧基色满（苯并色满）的抗炎及其他药理作用

Anti-inflammatory and some other pharmacological effects of 3,4-trans-2,2-dimethyl-3-phenyl-4-(p-(beta-pyrrolidinoethoxy)-phenyl)-7-methoxy-chroman (Centchroman).

作者信息

Dhawan B N, Srimal R C

出版信息

Br J Pharmacol. 1973 Sep;49(1):64-73. doi: 10.1111/j.1476-5381.1973.tb08268.x.

DOI:10.1111/j.1476-5381.1973.tb08268.x
PMID:4787565
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1776417/
Abstract
  1. Anti-inflammatory, analgesic, antipyretic and other pharmacological activities of a new chroman derivative, Centchroman, have been described.2. Centchroman was found to possess significant anti-inflammatory action in the carrageenin-induced oedema test in mice and rats. It inhibited granuloma formation in the cotton pellet test. The anti-arthritic activity was also evident in formaldehyde-induced arthritis and adjuvant-induced arthritis in rats.3. Centchroman had a lower ulcerogenic index than phenylbutazone.4. The mechanism of the anti-inflammatory action of Centchroman seemed to be independent of endogenous adrenocortical hormones or of its weak oestrogenic activity.5. Centchroman antagonized phenylquinone writhing and bradykinin-induced bronchospasm but was devoid of any antipyretic activity.
摘要

  1. 已描述了一种新型苯并二氢吡喃衍生物——醋炔诺酮的抗炎、镇痛、解热及其他药理活性。

  2. 发现在角叉菜胶诱导的小鼠和大鼠水肿试验中，醋炔诺酮具有显著的抗炎作用。它在棉球试验中抑制肉芽肿形成。在大鼠甲醛诱导的关节炎和佐剂诱导的关节炎中，其抗关节炎活性也很明显。

  3. 醋炔诺酮的致溃疡指数低于保泰松。

  4. 醋炔诺酮的抗炎作用机制似乎与内源性肾上腺皮质激素或其微弱的雌激素活性无关。

  5. 醋炔诺酮可拮抗苯醌扭体反应和缓激肽诱导的支气管痉挛，但无任何解热活性。