Gorthy W C
Invest Ophthalmol Vis Sci. 1979 Sep;18(9):939-46.
Prenatal and early postnatal devpelopment of eyes of Wistar rats with X-ray-induced cataract mutation was assessed histologically, to determine the events leading to cataract formation. A significant phenomenon appeared to be retinal folding, which occurred regularly at 14 to 15 days of gestation and might have pushed the lens against the cornea. A corneal reaction with the lens was indicated by corneal adhesions to the lens, seen frequently during and shortly after the period of retinal folding, and could have stimulated the epithelial hyperplasia that leads invariably to anterior polar cataract in these animals. Changes in the lens fiber cells, which could have been generated by the epithelial hyperplasia, included the sporadic detachment of newly developing fibers from the lens epithelium and the eventual swelling of the anterior ends of fibers still attached to the epithelium. The detached fibers became fusiform and developed postnatally into posterior, suture-associated vacuoles. Anterior uveitis was noted postnatally in some eyes and probably contributed to the subsequent development of the cataract. The results are discussed in the light of congenital anterior polar cataract formation reported in humans and other animals.
对经X射线诱导产生白内障突变的Wistar大鼠眼睛的产前和产后早期发育进行了组织学评估，以确定导致白内障形成的事件。一个显著的现象似乎是视网膜折叠，这种情况在妊娠14至15天时经常发生，可能会将晶状体推向角膜。视网膜折叠期间及之后不久经常可见角膜与晶状体粘连，这表明角膜与晶状体发生了反应，并且可能刺激了上皮增生，而这种增生在这些动物中总是会导致前极性白内障。由上皮增生可能产生的晶状体纤维细胞变化包括新发育的纤维偶尔从晶状体上皮脱离，以及仍附着于上皮的纤维前端最终肿胀。脱离的纤维变成梭形，并在出生后发育成与后缝线相关的空泡。出生后在一些眼睛中发现了前葡萄膜炎，这可能促使了白内障的后续发展。根据人类和其他动物中报道的先天性前极性白内障形成情况对结果进行了讨论。
