Hamaoka T, Inada T, Yamashita U, Kitagawa M
J Immunol. 1975 Jun;114(6):1771-8.
The role(s) of helper T lymphocytes in preventing or altering tolerance induction in DNP-specific B lymphocytes was studied. As DNP-reactive helper T cells were reactive against the DNP-portion of the DNP-D-GL molecule, we could probe definitively the physiological role of helper T cells in preventing tolerance induction in B lymphocytes by DNP-D-GL. The results demonstrated that the induction of DNP-specific B cell tolerance by DNP-D-GL can be completely prevented by the presence of DNP-reactive helper T cells, and provide evidence that one critical role of helper T cell participation in humoral responses to antigens is to circumvent the development of a tolerogenic signal that, in the absence of such T cell function, might otherwise ensue after binding of the antigenic determinants by specific B lymphocytes.
研究了辅助性T淋巴细胞在预防或改变针对二硝基苯（DNP）特异性B淋巴细胞的耐受诱导中的作用。由于DNP反应性辅助性T细胞对DNP-D-谷氨酸（DNP-D-GL）分子的DNP部分有反应，我们可以明确探究辅助性T细胞在预防DNP-D-GL诱导B淋巴细胞耐受中的生理作用。结果表明，DNP反应性辅助性T细胞的存在可完全阻止DNP-D-GL诱导的DNP特异性B细胞耐受，并提供证据表明辅助性T细胞参与对抗原的体液反应的一个关键作用是规避致耐受性信号的产生，在没有这种T细胞功能的情况下，特异性B淋巴细胞结合抗原决定簇后可能会产生这种信号。
