Austin J H, Yount B G, Thomas H M, Enson Y
Invest Radiol. 1979 Jan-Feb;14(1):9-17. doi: 10.1097/00004424-197901000-00003.
Chronic, diffuse, interstitial pulmonary diseases may cause an increase in mean pulmonary arterial pressure (PAP) and a decrease in pulmonary blood volume (PBV). We compared 12 cardiovascular and three parenchymal assessments on plain chest radiographs with values of PAP and PBV obtained during cardiac catheterization in 29 patients with such diseases (progressive systemic sclerosis 20, sarcoidosis six, miscellaneous three) and normal pulmonary venous pressures. PAP ranged from 10 to 40 torr (mean 19, SD +/- 7), PBV from 6.4 to 10.8% of total blood volume (mean 8.4, SD +/- 1.2). PBV was significantly related to eight radiologic variables. PAP was significantly related to the severity of parenchymal disease and size of the central pulmonary arteries, both of which were assessed radiologically. Diversion of blood flow to upper zones was significantly related to restriction of the pulmonary vascular bed, but was not necessarily a sign of increased PAP. In general, pulmonary hemodynamic abnormalities appeared proportional to the radiologic severity of parenchymal disease.
慢性、弥漫性间质性肺疾病可能导致平均肺动脉压（PAP）升高和肺血容量（PBV）降低。我们将29例此类疾病（进行性系统性硬化症20例、结节病6例、其他3例）且肺静脉压正常的患者的胸部X线平片上的12项心血管和3项实质评估结果与心导管检查时获得的PAP和PBV值进行了比较。PAP范围为10至40托（平均19，标准差±7），PBV占总血容量的6.4%至10.8%（平均8.4，标准差±1.2）。PBV与8个放射学变量显著相关。PAP与实质疾病的严重程度和中央肺动脉大小显著相关，这两者均通过放射学评估。血流向上叶区域分流与肺血管床受限显著相关，但不一定是PAP升高的迹象。一般来说，肺血流动力学异常似乎与实质疾病的放射学严重程度成正比。
