慢性阻塞性肺疾病患者使用异丙肾上腺素后的肺阻力和最大呼气流量
Pulmonary resistance and maximal expiratory flowrate following isoprenaline in patients with chronic obstructive lung disease.
作者信息
Stănescu D C, Clément J, Van de Woestijne K P
出版信息
Thorax. 1973 Nov;28(6):716-20. doi: 10.1136/thx.28.6.716.
, , 716-720. Pulmonary resistance, maximal expiratory flowrates (measured from flow-volume curves), and lung volumes were measured in 17 patients with chronic obstructive lung disease before and 20 minutes after isoprenaline aerosols. Forced vital capacity, maximum expiratory flowrates, and pulmonary resistance all changed significantly following isoprenaline. Using a discriminant analysis, we showed that the bronchodilator effect was reflected almost completely by only two indices, pulmonary resistance and maximum expiratory flowrate at 25% of the control vital capacity. The information provided by each was independent. When the change following bronchodilatation is expressed as a percentage, pulmonary resistance carried most of the information and for practical purposes this index may be used alone.
在17例慢性阻塞性肺疾病患者中，于吸入异丙肾上腺素气雾剂前及吸入后20分钟测量肺阻力、最大呼气流量（根据流量-容积曲线测量）和肺容积。异丙肾上腺素吸入后，用力肺活量、最大呼气流量和肺阻力均发生了显著变化。通过判别分析，我们发现支气管扩张作用几乎完全由两个指标反映，即肺阻力和控制肺活量25%时的最大呼气流量。每个指标所提供的信息是独立的。当支气管扩张后的变化以百分比表示时，肺阻力承载了大部分信息，实际上该指标可单独使用。 （原文中开头的逗号可能有误，推测应该是有具体测量指标等内容未完整给出，这里是按照完整的意思翻译） ，716 - 720。
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