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将5-羟色胺注入兔侧脑室后，其在最后区的摄取的细胞定位。

Cellular localization of the uptake of 5-hydroxytryptamine in the area postrema of the rabbit after injection into a lateral ventricle.

作者信息

Dow R C, Laszlo I, Ritchie I M

出版信息

Br J Pharmacol. 1973 Dec;49(4):580-7. doi: 10.1111/j.1476-5381.1973.tb08533.x.

DOI:10.1111/j.1476-5381.1973.tb08533.x
PMID:4788031
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1776590/
Abstract
  1. The cellular localization of 5-hydroxytryptamine (5-HT) was investigated in the area postrema of the rabbit after intraventricular injection under different experimental conditions.2. 5-HT was found to be accumulated in different parts in and near to the area postrema, e.g. in glial cells, dorsal surface of the area postrema and ependyma of the central canal.3. The concentrations of 5-HT and 5-hydroxy indol-3-yl acetic acid (5-HIAA) were measured in different parts of the brain and CSF in control and in 5-HT treated animals with and without pargyline pretreatment. Intraventricular injection of 5-HT increased the concentration of 5-HT and 5-HIAA in the brain and in the CSF; pretreatment with pargyline further increased the concentrations of 5-HT but decreased the concentration of 5-HIAA.
摘要

  1. 在不同实验条件下经脑室注射后，研究了家兔最后区中5-羟色胺（5-HT）的细胞定位。

  2. 发现5-HT积聚在最后区及其附近的不同部位，如神经胶质细胞、最后区的背表面和中央管的室管膜。

  3. 在对照动物以及经和未经帕吉林预处理的5-HT处理动物中，测量了大脑不同部位和脑脊液中5-HT和5-羟吲哚-3-乙酸（5-HIAA）的浓度。经脑室注射5-HT可增加大脑和脑脊液中5-HT和5-HIAA的浓度；用帕吉林预处理可进一步提高5-HT的浓度，但降低5-HIAA的浓度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d911/1776590/b82efcd11236/brjpharm00542-0026-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d911/1776590/d96f0137177a/brjpharm00542-0025-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d911/1776590/b82efcd11236/brjpharm00542-0026-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d911/1776590/d96f0137177a/brjpharm00542-0025-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d911/1776590/b82efcd11236/brjpharm00542-0026-a.jpg

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Cellular localization of the uptake of 5-hydroxytryptamine in the area postrema of the rabbit after injection into a lateral ventricle.将5-羟色胺注入兔侧脑室后，其在最后区的摄取的细胞定位。
Br J Pharmacol. 1973 Dec;49(4):580-7. doi: 10.1111/j.1476-5381.1973.tb08533.x.
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本文引用的文献

1
Cellular localization of monoamines in the area postrema of certain mammals.某些哺乳动物最后区中单胺的细胞定位。
J Comp Neurol. 1965 Dec;125(3):337-53. doi: 10.1002/cne.901250305.
2
The accumulation of ( 14 C)5-hydroxyindol-3-ylacetic acid by the rabbit choroid plexus in vitro.家兔脉络丛体外对（14C）5-羟吲哚-3-乙酸的摄取
J Physiol. 1971 Jul;216(1):201-11. doi: 10.1113/jphysiol.1971.sp009518.
3
A simple method allowing perfusion of cerebral ventricles of the conscious rabbit.一种可对清醒家兔脑室进行灌注的简单方法。
脑室内注射后家兔大脑不同部位对5-羟色胺的摄取
Br J Pharmacol. 1976 Apr;56(4):443-7. doi: 10.1111/j.1476-5381.1976.tb07456.x.
J Appl Physiol. 1970 Apr;28(4):528-9. doi: 10.1152/jappl.1970.28.4.528.
4
Investigations on the histochemical demonstration of noradrenaline and 5-hydroxy-tryptamine in the area postrema of the rabbit by fluorescence microscopy.用荧光显微镜对兔最后区去甲肾上腺素和5-羟色胺进行组织化学显示的研究。
Br J Pharmacol. 1972 May;45(1):186P-187P.
5
Cellular localization of the uptake of 5-hydroxytryptamine in the area postrema of the rabbit after injection into a lateral ventricle.向兔侧脑室内注射5-羟色胺后，其在最后区摄取的细胞定位。
Br J Pharmacol. 1972 May;45(1):178P-179P.
6
Effects of electrical stimulation of rat midbrain on 5-hydroxytryptamine synthesis as determined by a sensitive radioisotope method.用灵敏的放射性同位素法测定大鼠中脑电刺激对5-羟色胺合成的影响。
J Neurochem. 1972 Feb;19(2):265-72. doi: 10.1111/j.1471-4159.1972.tb01336.x.
7
Localization of 5-hydroxytryptamine uptake in rat brain after intraventricular injection.脑室内注射后大鼠脑中5-羟色胺摄取的定位
J Pharm Pharmacol. 1967 May;19(5):335-7. doi: 10.1111/j.2042-7158.1967.tb08097.x.
8
Glial cell function: uptake of transmitter substances.神经胶质细胞功能：递质物质的摄取。
Proc Natl Acad Sci U S A. 1971 Nov;68(11):2686-90. doi: 10.1073/pnas.68.11.2686.