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2
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UPTAKE AND ACCUMULATION OF CATECHOLAMINES IN PERIPHERAL ADRENERGIC NEURONS OF RESERPINIZED ANIMALS, STUDIED WITH A HISTOCHEMICAL METHOD.用组织化学方法研究利血平化动物外周肾上腺素能神经元中儿茶酚胺的摄取和蓄积
Biochem Pharmacol. 1964 Jun;13:841-4. doi: 10.1016/0006-2952(64)90026-7.
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Cation dependence of sympathetic transmitter retention by slices of rat ventricle.大鼠心室切片对交感神经递质保留的阳离子依赖性
Br J Pharmacol Chemother. 1967 Mar;29(3):309-18. doi: 10.1111/j.1476-5381.1967.tb01962.x.
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Uptake and metabolism of catecholamines in the perfused hearts of different species.不同物种灌注心脏中儿茶酚胺的摄取与代谢
Br J Pharmacol. 1970 Apr;38(4):810-21. doi: 10.1111/j.1476-5381.1970.tb09890.x.
4
The role of internal and external Na+ and K+ on the uptake of [3H] noradrenaline by synaptosomes prepared from rat brain.
Biochim Biophys Acta. 1970;196(2):285-95. doi: 10.1016/0005-2736(70)90016-7.
5
The mode of sodium dependency of the adrenergic neuron amide carrier. Evidence for a second, sodium-dependent, optically specific and reserpine-sensitive system.肾上腺素能神经元酰胺载体的钠依赖性模式。存在第二个钠依赖性、光学特异性且对利血平敏感系统的证据。
J Pharmacol Exp Ther. 1969 Dec;170(2):239-45.
6
Differences in the uptake, storage and metabolism of (+)- and (-)-noradrenaline.（+）-去甲肾上腺素与（-）-去甲肾上腺素在摄取、储存及代谢方面的差异。
Br J Pharmacol. 1971 Dec;43(4):845-55. doi: 10.1111/j.1476-5381.1971.tb07221.x.
7
Effect of local anaesthetics on the accumulation of ( 3 H)-metaraminol by rabbit atria and vasa deferentia.局部麻醉药对兔心房和输精管中（3H）-间羟胺蓄积的影响。
Experientia. 1972 Oct 15;28(10):1191-2. doi: 10.1007/BF01946163.
8
Metabolic requirements for the uptake of noradrenaline by isolated atria and vas deferens of the rabbit.家兔离体心房和输精管摄取去甲肾上腺素的代谢需求。
Pharmacology. 1972;7(2):78-88. doi: 10.1159/000136275.
9
Some evidence of the active uptake of noradrenaline in the guinea-pig isolated trachea.在豚鼠离体气管中去甲肾上腺素主动摄取的一些证据。
Br J Pharmacol. 1972 May;45(1):71-82. doi: 10.1111/j.1476-5381.1972.tb09578.x.
10
Effects of external Na + and K + on the initial rates of noradrenaline uptake by synaptosomes prepared from rat brain.细胞外钠离子和钾离子对大鼠脑制备的突触体摄取去甲肾上腺素初始速率的影响。
Biochim Biophys Acta. 1972 Apr 14;266(1):116-27. doi: 10.1016/0005-2736(72)90126-5.

家兔心房肾上腺素能神经去甲肾上腺素的释放机制。

Mechanism of efflux of noradrenaline from adrenergic nerves in rabbit atria.

作者信息

Paton D M

出版信息

Br J Pharmacol. 1973 Dec;49(4):614-27. doi: 10.1111/j.1476-5381.1973.tb08537.x.

DOI:10.1111/j.1476-5381.1973.tb08537.x
PMID:4788035
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1776596/
Abstract
  1. The mechanism of efflux of (-)-[(3)H]-noradrenaline was examined in rabbit atria, which were pretreated with reserpine and pargyline.2. Between 40 and 100 min, efflux occurred predominantly from a single intraneuronal compartment.3. Efflux was rapidy increased by (-)- and (+)-noradrenaline, tyramine and (+/-)-metaraminol, but not by (+/-)-isopropylnoradrenaline or (+/-)-normetanephrine. The increase in efflux produced by (-)-noradrenaline was inhibited by cocaine and desipramine but not by lidocaine.4. Spontaneous effluxes, and those accelerated by (-)-noradrenaline, were temperature-sensitive.5. Efflux was increased by ouabain, omission of K(+), metabolic inhibition and lowering of the external Na(+) concentration. These effects were significantly reduced by cocaine and desipramine but not by lidocaine.6. These findings provide evidence that the efflux of [(3)H]-noradrenaline from adrenergic nerves occurs by a cocaine-sensitive, carrier-mediated process. The characteristics of the efflux process are compatible with, but not conclusive proof for, the Na(+)-gradient hypothesis.
摘要

  1. 在用利血平和优降宁预处理的兔心房中，研究了（-）-[（3）H]-去甲肾上腺素的流出机制。

  2. 在40至100分钟之间，流出主要发生在单个神经元内区室。

  3. （-）-和（+）-去甲肾上腺素、酪胺和（+/-）-间羟胺可迅速增加流出，但（+/-）-异丙肾上腺素或（+/-）-去甲变肾上腺素则无此作用。（-）-去甲肾上腺素引起的流出增加被可卡因和地昔帕明抑制，但未被利多卡因抑制。

  4. 自发流出以及由（-）-去甲肾上腺素加速的流出对温度敏感。

  5. 哇巴因、钾离子缺失、代谢抑制和细胞外钠离子浓度降低会增加流出。这些作用被可卡因和地昔帕明显著降低，但未被利多卡因降低。

  6. 这些发现提供了证据，表明来自肾上腺素能神经的[（3）H]-去甲肾上腺素的流出是通过可卡因敏感的载体介导过程发生的。流出过程的特征与钠离子梯度假说相符，但并非确凿证据。