两种基因不同的大鼠实验性关节炎中的血液变化
Blood changes in experimental arthritis in two types of genetically different rats.
作者信息
Eisen V, Freeman P C, Loveday C, West G B
出版信息
Br J Pharmacol. 1973 Dec;49(4):688-95. doi: 10.1111/j.1476-5381.1973.tb08545.x.
Abstract
- Rats genetically resistant to dextran and other agents producing the anaphylactoid reaction (NR rats), have a higher polymorph count than do rats which react to these agents (R rats).2. NR rats do not develop polyarthritis when a hind paw is injected intradermally with Freund's adjuvant.3. The polyarthritis produced by an intravenous injection of Mycoplasma arthritidis culture develops more slowly in NR rats than in R rats.4. It is not clear whether the higher polymorph count in NR rats is a main factor in determining their resistance to adjuvant-induced arthritis.
摘要
对右旋糖酐和其他能引发类过敏反应的物质具有遗传抗性的大鼠（NR大鼠），其多形核细胞计数高于对这些物质有反应的大鼠（R大鼠）。
当在后爪皮内注射弗氏佐剂时，NR大鼠不会发生多关节炎。
通过静脉注射关节炎支原体培养物产生的多关节炎在NR大鼠中比在R大鼠中发展得更慢。
尚不清楚NR大鼠中较高的多形核细胞计数是否是决定其对佐剂诱导性关节炎抗性的主要因素。
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