Knight P M, Link W J
J Am Intraocul Implant Soc. 1979 Apr;5(2):123-30. doi: 10.1016/s0146-2776(79)80051-8.
Two methods of surface modification of PMMA, permanent and temporary, were investigated for use on intraocular lenses to reduce corneal endothelial damage due to corneal-IOL touch. Monomer grafting using gamma irradiation was found to produce permanently hydrophilic surfaces. Temporary surface modifications developed and tested were peelable and dissolvable coatings. Test samples were touched to freshly excised rabbit corneas to evaluate the effectiveness of the various surface modifications in reducing endothelial cell damage. This touch testing was performed using static testing in which the test sample was touched to the cornea without movement and dynamic testing in which there was relative movement between the cornea and the test sample. While unmodified PMMA did significant cell damage in both static and dynamic tests perpamently modified (hydrophilic grafted) surfaces were found to perform well in the static, but not in the dynamic tests. Dissolvable coatings performed well in both tests, even with very thin coatings. There was little differentiation between the various water-soluble coatings tested. Due to its characteristics and rate of dissolution, polyvinyl alcohol appears to be an optimum material for coating IOLs. A series of in vitro and in vivo tests performed to assess its safety indicate that PVA is nontoxic and safe in animal eyes.
研究了聚甲基丙烯酸甲酯（PMMA）的两种表面改性方法，即永久性和临时性改性方法，用于人工晶状体，以减少因角膜与人工晶状体接触而导致的角膜内皮损伤。发现使用γ射线辐照进行单体接枝可产生永久性亲水表面。开发并测试的临时性表面改性方法是可剥离和可溶解的涂层。将测试样品接触刚切除的兔角膜，以评估各种表面改性方法在减少内皮细胞损伤方面的有效性。这种接触测试采用静态测试，即测试样品静止地接触角膜，以及动态测试，即角膜和测试样品之间存在相对运动。在静态和动态测试中，未改性的PMMA都会造成显著的细胞损伤，而永久性改性（亲水接枝）表面在静态测试中表现良好，但在动态测试中则不然。可溶解涂层在两种测试中都表现良好，即使涂层非常薄。所测试的各种水溶性涂层之间几乎没有差异。由于其特性和溶解速度，聚乙烯醇似乎是用于涂覆人工晶状体的最佳材料。为评估其安全性而进行的一系列体外和体内测试表明，聚乙烯醇在动物眼中无毒且安全。
